INT15652

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Context Info
Confidence 0.68
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 37
Total Number 37
Disease Relevance 33.39
Pain Relevance 5.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ENO2) small molecule metabolic process (ENO2) lyase activity (ENO2)
plasma membrane (ENO2) intracellular (ENO2) carbohydrate metabolic process (ENO2)
Anatomy Link Frequency
neuron 16
neuronal 2
brain 1
motor neurons 1
leukocyte 1
ENO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 4 99.68 Very High Very High Very High
Pain 24 99.00 Very High Very High Very High
Enkephalin 3 99.00 Very High Very High Very High
Inflammation 67 97.80 Very High Very High Very High
Spinal cord 9 97.32 Very High Very High Very High
agonist 12 96.92 Very High Very High Very High
Angina 3 95.04 Very High Very High Very High
Thalamus 2 94.72 High High
calcitonin gene related peptide 1 94.52 High High
Central nervous system 27 94.00 High High
Disease Link Frequency Relevance Heat
Cancer 182 100.00 Very High Very High Very High
Lymphatic System Cancer 8 99.96 Very High Very High Very High
Brain Injury 58 99.72 Very High Very High Very High
Coma 90 99.66 Very High Very High Very High
Prostate Cancer 2 99.52 Very High Very High Very High
Myoclonus 138 99.34 Very High Very High Very High
Head Trauma 2 99.12 Very High Very High Very High
Hypothermia 136 99.04 Very High Very High Very High
Pain 5 99.00 Very High Very High Very High
Lymphadenopathy 4 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although rarely observed in patients with malignant lymphoma, increased serum NSE levels may serve as an index of chemotherapeutic effectiveness.
Positive_regulation (increased) of NSE associated with lymphatic system cancer
1) Confidence 0.68 Published 1999 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 10586598 Disease Relevance 1.13 Pain Relevance 0.06
Maximum androgen blockade (MAB) resulted in a decrease of PSA (5.13 ng/ml) but an increase of NSE (810 ng/ml).
Positive_regulation (increase) of NSE
2) Confidence 0.67 Published 2007 Journal Hinyokika Kiyo Section Abstract Doc Link 17702184 Disease Relevance 1.48 Pain Relevance 0.08
Tumor markers including lactate dehydrogenase (LDH), cancer antigen-125 (CA-125), beta-subunit of human chorionic gonadotropin (beta-hCG) and neuron-specific enolase (NSE) were elevated.
Positive_regulation (elevated) of NSE in neuron associated with cancer
3) Confidence 0.52 Published 2004 Journal J. Pediatr. Surg. Section Abstract Doc Link 15359410 Disease Relevance 0.62 Pain Relevance 0.14
Tumor markers including lactate dehydrogenase (LDH), cancer antigen-125 (CA-125), beta-subunit of human chorionic gonadotropin (beta-hCG) and neuron-specific enolase (NSE) were elevated.
Positive_regulation (elevated) of neuron-specific enolase in neuron associated with cancer
4) Confidence 0.52 Published 2004 Journal J. Pediatr. Surg. Section Abstract Doc Link 15359410 Disease Relevance 0.62 Pain Relevance 0.14
Immunohistochemically, the tumor cells proved positive for S-100, NSE, GFAP, MBP, chromogranin A and synaptophysin, and negative for CEA, keratin, HMB-45, G-CSF, and GM-CSF.
Positive_regulation (positive) of NSE associated with cancer
5) Confidence 0.49 Published 2005 Journal Pathol. Res. Pract. Section Abstract Doc Link 15991844 Disease Relevance 1.28 Pain Relevance 0.25
Very few fibres were found that were reactive for neuron-specific enolase, indicating that other fibre population (e.g. excitatory cholinergic motor neurons) are also damaged in achalasia.
Positive_regulation (reactive) of neuron-specific enolase in motor neurons associated with increased venous pressure under development
6) Confidence 0.48 Published 1996 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 8743921 Disease Relevance 0.54 Pain Relevance 0.45
The small cell carcinomatous component was positive for chromogranin, neuron specific enolase, synaptophysin, and pancytokeratin but negative for high molecular-weight cytokeratin (K-903) by immunohistochemistry.
Positive_regulation (positive) of neuron specific enolase in neuron
7) Confidence 0.47 Published 2001 Journal J. Korean Med. Sci. Section Abstract Doc Link 11748366 Disease Relevance 0.59 Pain Relevance 0.07
According to our results, patients treated with hypothermia stand a good chance of recovery despite higher levels of NSE.
Positive_regulation (levels) of NSE associated with hypothermia
8) Confidence 0.47 Published 2010 Journal Crit Care Section Body Doc Link PMC2887191 Disease Relevance 0.89 Pain Relevance 0.04
Extensive neuronal loss is also reflected by the regular elevation of serum NSE in our patients, which, as an isolated phenomenon, is known to indicate a poor prognosis [20-25].
Positive_regulation (elevation) of NSE in neuronal
9) Confidence 0.45 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1190185 Disease Relevance 1.07 Pain Relevance 0.18
In the last few decades, several clinical and electrophysiological variables have been reported to be strongly associated with a poor outcome in comatose survivors of cardiac arrest; these include absence of pupillary and corneal reflexes, absent motor response to pain [2-5], myoclonus or epilepticus status [6,7], an increase of neuron specific enolase (NSE) in serum [8], and a burst-suppression or isoelectric electro-encephalography (EEG) pattern [7,9,10].
Positive_regulation (increase) of NSE in neuron associated with pain, myoclonus, myocardial infarction and coma
10) Confidence 0.45 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2630986 Disease Relevance 0.90 Pain Relevance 0.10
The only significant abnormal laboratory finding was elevation of serum NSE (24.5 ng/ml).
Positive_regulation (elevation) of NSE
11) Confidence 0.45 Published 1991 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 1753509 Disease Relevance 0.35 Pain Relevance 0.09
Immunohistochemistry stains for keratins AE-1/AE-3 were negative, while S-100 and NSE were positive.
Positive_regulation (positive) of NSE in AE-1
12) Confidence 0.45 Published 2006 Journal World J. Gastroenterol. Section Abstract Doc Link 17203537 Disease Relevance 1.15 Pain Relevance 0.17
In patients with (i) unfavourable clinical signs (bilateral absence of the pupil light reaction and/or bilateral absence of the corneal reflex and/or loss of the vestibular-ocular reflex and/or no motor response on painful stimuli), (ii) an unfavourable EEG pattern (BS-EEG, generalized epileptiform discharges, alpha-coma-EEG), and (iii) elevated NSE serum levels, we restrict treatment to mechanical ventilation and intravenous fluids until they regain spontaneous breathing or die.


Positive_regulation (elevated) of NSE in pupil associated with pain and coma
13) Confidence 0.45 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1190185 Disease Relevance 0.37 Pain Relevance 0.10
The granular cells of the current case were positive for neuron-specific enolase (NSE), S-100 protein, GFAP, vimentin, CD 68, lysozyme, and alpha-1-antitrypsin.
Positive_regulation (positive) of neuron-specific enolase in neuron
14) Confidence 0.40 Published 2008 Journal Neuropathology Section Abstract Doc Link 18466222 Disease Relevance 0.87 Pain Relevance 0.08
The granular cells of the current case were positive for neuron-specific enolase (NSE), S-100 protein, GFAP, vimentin, CD 68, lysozyme, and alpha-1-antitrypsin.
Positive_regulation (positive) of NSE in neuron
15) Confidence 0.40 Published 2008 Journal Neuropathology Section Abstract Doc Link 18466222 Disease Relevance 0.87 Pain Relevance 0.08
[Increased neuron-specific enolase levels in patients with long-standing pyothorax-associated lymphoma].
Positive_regulation (Increased) of enolase in neuron associated with lymphatic system cancer and empyema thoracis
16) Confidence 0.40 Published 1999 Journal Nihon Kokyuki Gakkai Zasshi Section Title Doc Link 10586598 Disease Relevance 1.06 Pain Relevance 0.10
Immunohistochemicallly, the cells were positive for NSE and placental alkaline phosphatase (PALP) but were negative for CA-125, beta-hCG, S-100, glial fibrillary acidic protein, and vimentin.
Positive_regulation (positive) of NSE
17) Confidence 0.37 Published 2004 Journal J. Pediatr. Surg. Section Abstract Doc Link 15359410 Disease Relevance 0.62 Pain Relevance 0.12
Increased levels of NSE are associated with deterioration of CF after cardiac surgery [46].
Positive_regulation (Increased) of NSE
18) Confidence 0.35 Published 2010 Journal Crit Care Section Body Doc Link PMC2911704 Disease Relevance 0.64 Pain Relevance 0.41
Also, increased NSE levels are associated with brain injury in septic patients, but an association between NSE and CFs in septic patients has not been examined.


Positive_regulation (increased) of NSE in brain associated with brain injury
19) Confidence 0.35 Published 2010 Journal Crit Care Section Body Doc Link PMC2911704 Disease Relevance 0.68 Pain Relevance 0.43
Interestingly, elevated NSE levels were recently shown to predict death in one small study (n = 29) of patients with severe sepsis [76], even though these patients had no acute CNS disorders, such as stroke or neurotrauma.
Positive_regulation (elevated) of NSE associated with stroke, central nervous system, sepsis and death
20) Confidence 0.35 Published 2006 Journal Crit Care Section Body Doc Link PMC1794449 Disease Relevance 1.31 Pain Relevance 0.17

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