INT156533

Context Info Confidence 0.69 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 4.35 Pain Relevance 0.74

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)

Anatomy Link Frequency plasma 2 chest 1 mononuclear cells 1 LEP (Homo sapiens)

Pain Link Frequency Relevance Heat spinal inflammation 2 97.04 Inflammation 17 94.00 cytokine 18 93.48 Pain 41 90.48 agonist 26 79.60 nociceptor 2 75.76 Endocannabinoid 35 57.64 Neuropeptide y 3 29.04 Cannabinoid receptor 7 6.72 primary somatosensory cortex 6 5.00

Disease Link Frequency Relevance Heat Obesity 557 100.00 Apnoea 31 99.84 Low Back Pain 2 97.04 INFLAMMATION 21 94.00 Insulin Resistance 7 90.76 Pain 34 90.48 Recurrence 2 88.68 Congenital Anomalies 1 85.92 Benign Prostatic Hypertrophy 7 85.40 Nociception 2 83.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, as expected BMI and leptin mRNA levels in VAT were highly correlated (r = 0.51; p = 1.1 × 10-5).

Transcription (levels) of leptin associated with obesity

1) Confidence 0.69 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2925326 Disease Relevance 0.62 Pain Relevance 0

The timing when the peak of the LEP appears

Transcription (peak) of LEP

2) Confidence 0.62 Published 2007 Journal Computational Intelligence and Neuroscience Section Body Doc Link PMC2271124 Disease Relevance 0.31 Pain Relevance 0.28

Leptin levels were low in patients who had sequela lesion on chest radiographs.

Transcription (levels) of Leptin in chest

3) Confidence 0.51 Published 2007 Journal Mediators of Inflammation Section Abstract Doc Link PMC1804295 Disease Relevance 0.62 Pain Relevance 0.03

The present study was conducted to evaluate the basal serum leptin levels in OSA patients and its possible relation to OSA severity.

Transcription (levels) of serum leptin associated with apnoea

4) Confidence 0.47 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2567288 Disease Relevance 0.94 Pain Relevance 0

Interestingly, however, the concentrations of AEA, OEA and PEA, did not correlate negatively with plasma leptin levels, nor with M values, but did correlate positively with SAT leptin mRNA levels.

Transcription (levels) of SAT leptin in plasma associated with obesity

5) Confidence 0.21 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 0.85 Pain Relevance 0.06

OBJECTIVES: This study was performed to investigate whether leptin mRNA expression is increased from peripheral blood mononuclear cells (PBMCs) of patients with active ankylosing spondylitis (AS) and whether it stimulates the production of pro-inflammatory cytokines.

Transcription (expression) of leptin in mononuclear cells associated with spinal inflammation, inflammation and cytokine

6) Confidence 0.17 Published 2009 Journal Joint Bone Spine Section Abstract Doc Link 19059800 Disease Relevance 0.34 Pain Relevance 0.30

Unlike positive control human WAT cDNA analyzed in parallel, Tusc5 mRNA was nondetectable in HepG2 cells under all conditions (transcripts for leptin and AdipoQ/adiponectin were also not detected).

Transcription (transcripts) of leptin associated with obesity

7) Confidence 0.15 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.32 Pain Relevance 0.07

Since the first description of HoLEP in 1995 by Gilling, the technique of laser prostatectomy has been evolving [7].

Transcription (description) of HoLEP

8) Confidence 0.07 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2963781 Disease Relevance 0.25 Pain Relevance 0

Outcome measures were the relative expression of clock gene mRNA (hperiod1, hperiod2, hclock) and the levels of serum cortisol, plasma ACTH, beta-endorphin (beta-EP), leptin, neuropeptide Y, interleukin-2 (IL-2), and tumor necrosis factor (TNF) in these subjects.

Transcription (expression) of leptin in plasma

9) Confidence 0.04 Published 2009 Journal Biol. Psychiatry Section Body Doc Link 19135652 Disease Relevance 0.09 Pain Relevance 0

General Comments

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