INT156564

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Context Info
Confidence 0.36
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.36
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (BACE1) peptidase activity (BACE1) Golgi apparatus (BACE1)
endoplasmic reticulum (BACE1) enzyme binding (BACE1)
Anatomy Link Frequency
cleavage 4
BACE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 198 99.84 Very High Very High Very High
Abeta 8 99.16 Very High Very High Very High
Nav1.1 8 95.28 Very High Very High Very High
tetrodotoxin 3 90.16 High High
imagery 4 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 8 89.80 High High
Alzheimer's Dementia 11 80.00 Quite High
Neuroblastoma 6 50.56 Quite High
Disease Progression 2 12.08 Low Low
Injury 2 6.56 Low Low
Stress 6 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low
Brain Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it will be interesting to see whether the blockage of BACE1 cleavage in Nav?
Spec (whether) Negative_regulation (blockage) of Gene_expression (cleavage) of BACE1 in cleavage associated with sodium channel
1) Confidence 0.36 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0 Pain Relevance 0.63
Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit

Background

Negative_regulation (Identification) of Gene_expression (cleavage) of BACE1 in cleavage associated with sodium channel
2) Confidence 0.36 Published 2010 Journal Mol Neurodegener Section Title Doc Link PMC3022600 Disease Relevance 0.14 Pain Relevance 0.14
Inhibition of cathepsin B (catB) activity with CA074Me or attenuation of catB expression through small interfering RNA produced decreases in Abeta release, similar to levels produced with suppression of beta-site APP-cleaving enzyme 1 (BACE1) expression.
Negative_regulation (suppression) of Gene_expression (expression) of BACE1 associated with abeta
3) Confidence 0.07 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19064719 Disease Relevance 0.22 Pain Relevance 0.54

General Comments

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