INT156567

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.22
Pain Relevance 0.54

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endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Bace1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Abeta 8 99.16 Very High Very High Very High
tetrodotoxin 3 90.16 High High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 3 80.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of cathepsin B (catB) activity with CA074Me or attenuation of catB expression through small interfering RNA produced decreases in Abeta release, similar to levels produced with suppression of beta-site APP-cleaving enzyme 1 (BACE1) expression.
Negative_regulation (suppression) of Gene_expression (expression) of beta-site APP-cleaving enzyme 1 associated with abeta
1) Confidence 0.32 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19064719 Disease Relevance 0.22 Pain Relevance 0.54

General Comments

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