INT156579

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 6.53
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) cell adhesion (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
platelet 3
endothelial cells 2
plasma 1
macrophage 1
pancreas 1
Selp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 128 98.72 Very High Very High Very High
Inflammatory mediators 13 91.52 High High
allodynia 6 90.08 High High
Angina 4 85.76 High High
Inflammatory response 38 85.16 High High
cytokine 79 82.04 Quite High
antagonist 5 79.92 Quite High
medulla 15 79.64 Quite High
agonist 41 78.40 Quite High
Spinal cord 81 76.12 Quite High
Disease Link Frequency Relevance Heat
Adhesions 72 99.16 Very High Very High Very High
INFLAMMATION 186 98.72 Very High Very High Very High
Stroke 84 98.60 Very High Very High Very High
Urological Neuroanatomy 17 98.56 Very High Very High Very High
Endotoxemia 71 96.40 Very High Very High Very High
Hemolytic Uremic Syndrome 82 94.88 High High
Thrombosis 105 93.52 High High
Neuropathic Pain 6 90.08 High High
Diabetes Mellitus 6 89.12 High High
Stress 34 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P-selectin and ICAM-1 were immunolocalized to endothelial cells, and were double labelled with von Willebrand factor.
Localization (labelled) of P-selectin in endothelial cells
1) Confidence 0.73 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.55 Pain Relevance 0.53
P-selectin and ICAM-1 were immunolocalized to endothelial cells, and were double labelled with von Willebrand factor.
Localization (immunolocalized) of P-selectin in endothelial cells
2) Confidence 0.73 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.55 Pain Relevance 0.52
Of these, increased expression of P-selectin, ICAM-1 and CCL12 after carrageenan injection could be verified by real-time RT-PCR on both the right and left sides, and increased in P-selectin and ICAM-1 further verified by Western blot analysis.
Localization (verified) of P-selectin
3) Confidence 0.73 Published 2009 Journal Pain Section Abstract Doc Link 19167818 Disease Relevance 0.56 Pain Relevance 0.51
Because P-selectin shed from platelets serves as the main source for circulating P-selectin and platelet activation results in up to 50% secretion of intracellular P-selectin [23], it is reasonable to assume that a major part of the increase in sP-selectin during endotoxemia might also be due to platelet activation.
Localization (secretion) of P-selectin in platelet associated with endotoxemia
4) Confidence 0.36 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.63 Pain Relevance 0.07
To differentiate whether sP-selectin originated from endothelial cells or platelets, which both have been shown to release a soluble form of P-selectin into the plasma [23], we additionally performed immunohistochemical analyses.
Localization (release) of P-selectin in plasma
5) Confidence 0.36 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.51 Pain Relevance 0.15
Immunohistochemical localization of P-selectin, Intercellular Cell Adhesion Molecule (ICAM)-1, IL-1 ?
Localization (localization) of P-selectin associated with adhesions
6) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 0.65 Pain Relevance 0.07
In zymosan-treated mice, an increase of immunohistochemical staining for ICAM-1 and P-selectin was demonstrated in the pancreas (Figure 8A, 9A respectively) lung (Figure 8B, 9B respectively) and gut(Figure 8C, 9C respectively), (see arrows) while the immunostainings for ICAM-1 and P-selectin were markedly reduced in pancreas (Figure 8D, 9D respectively) lung (Figure 8E, 9E respectively) and gut(Figure 8F, 9F respectively) tissues obtained from mice, that were treated with GW0742.
Localization (increase) of P-selectin in pancreas
7) Confidence 0.36 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.27 Pain Relevance 0.08
Immunohistochemical localization of nitrotyrosine, PARP, ICAM-1, P-Selectin, Bax, Bcl-2, TNF-?
Localization (localization) of P-Selectin
8) Confidence 0.34 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0 Pain Relevance 0.03
Immunohistochemical analysis of P-selectin and PAI-1 expression
Localization (analysis) of P-selectin
9) Confidence 0.34 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.12 Pain Relevance 0
Upon platelet activation, P-selectin is released and expressed on the cell surface.
Localization (released) of P-selectin in platelet
10) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.77 Pain Relevance 0.17
LPS binds to platelets through the TLR4/P-selectin complex receptor [21] leading to platelet activation, demonstrated by release of CD40 ligand and P-selectin [21].
Localization (release) of P-selectin in platelets
11) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.58 Pain Relevance 0.09
Looking at the temporal profile of P-selectin, a biphasic release pattern can be distinguished with a first peak 15 minutes after the insult.
Localization (profile) of P-selectin
12) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.32 Pain Relevance 0.08
Serum level of Hs-CRP, GP IIb-IIIa MFI and CD62p positive rate were significantly lowered after treatment in both groups (P < 0.05), no significant difference was found between groups, though the lowering of Hs-CRP and GP IIb-IIIa MFI in the tested group displayed a further decreasing trend.
Localization (rate) of CD62p
13) Confidence 0.11 Published 2008 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 19065902 Disease Relevance 0.13 Pain Relevance 0
The important mediators released by platelets are P-selectin (CD62p), CD40p, platelet activating factor, macrophage chemotactic factor-1, interleukin-1, thrombospondin and fibronectin.
Localization (released) of P-selectin in macrophage
14) Confidence 0.03 Published 2004 Journal Thromb J Section Body Doc Link PMC406420 Disease Relevance 0.89 Pain Relevance 0.40

General Comments

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