INT156595

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2009
Negated 4
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.80
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CDX2)
Anatomy Link Frequency
colon 2
lung 1
CDX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 64 92.44 High High
abdominal pain 8 84.92 Quite High
Serotonin 1 73.84 Quite High
imagery 15 40.76 Quite Low
Piles 1 39.52 Quite Low
antagonist 2 18.88 Low Low
Opioid 4 6.64 Low Low
Inflammation 7 5.00 Very Low Very Low Very Low
psoriasis 6 5.00 Very Low Very Low Very Low
palliative 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 152 99.56 Very High Very High Very High
Cancer 373 98.92 Very High Very High Very High
Metastasis 24 97.54 Very High Very High Very High
Teratoma 2 96.68 Very High Very High Very High
Cyst 1 95.36 Very High Very High Very High
Colorectal Cancer 2 94.40 High High
Dermoids 4 91.52 High High
Lung Cancer 110 90.92 High High
Adenoma 8 86.08 High High
Abdominal Pain 8 84.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of Cdx2 may also be a functional change, since reduced expression of Cdx2 has been shown to be important in colon tumorigenesis [63].
Gene_expression (expression) of Cdx2 in colon
1) Confidence 0.69 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.35 Pain Relevance 0
There was no expression of CK20, CDX2 or CEA.
Neg (no) Gene_expression (expression) of CDX2
2) Confidence 0.61 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2709896 Disease Relevance 1.29 Pain Relevance 0.04
The induction of Cdx2 may also be a functional change, since reduced expression of Cdx2 has been shown to be important in colon tumorigenesis [63].
Gene_expression (expression) of Cdx2 in colon
3) Confidence 0.60 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.36 Pain Relevance 0
Thus, we suggest that CDKN2A EX2, CDX2, HOXA1 and OPCML are the top candidates from the 28 tested, and should be validated as DNA methylation markers for lung adenocarcinoma.
Gene_expression (tested) of CDX2 in lung associated with adenocarcinoma
4) Confidence 0.59 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2206053 Disease Relevance 0.42 Pain Relevance 0
Thirteen of the analyzed loci showed statistically significant differences in DNA methylation when AD samples were compared to all NTL samples: OPCML, CDX2, HOXA1, CDKN2A EX2, SFRP1, CDH13, TWIST1, LZTS1, RASSF1, SFRP4 and 5, ESR1, and CDH1.
Gene_expression (samples) of CDX2 associated with adenocarcinoma
5) Confidence 0.59 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2206053 Disease Relevance 1.16 Pain Relevance 0
The possibility of prostatic metastasis was considered and confirmed on immunohistochemical staining for PSA (Figure 2) and, given this, stains for CK7, CK20 and CDX2 immunoprofile were considered unnecessary.
Gene_expression (immunoprofile) of CDX2 associated with metastasis
6) Confidence 0.52 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1779271 Disease Relevance 0.77 Pain Relevance 0
The apomucines MUC5AC and MUC6 were positive in more than 50% of neoplastic cells, indicating a gastric foveolar phenotype while CDX2 and MUC2 were negative, indicating that intestinal phenotype was completely absent; also MUC1 was negative.
Neg (negative) Gene_expression (negative) of CDX2
7) Confidence 0.45 Published 2008 Journal Cases J Section Body Doc Link PMC2613149 Disease Relevance 0.42 Pain Relevance 0.04
Immunostaining for MUC1, MUC2, MUC5AC, MUC6, CDX2, CK-7, and CK-20 were performed on sections specimens that were dewaxed and rehydrated using Bio-clear (Bio-Optica, Milan, Italy) and graded alcohols.
Gene_expression (Immunostaining) of CDX2
8) Confidence 0.39 Published 2008 Journal Cases J Section Body Doc Link PMC2613149 Disease Relevance 0.19 Pain Relevance 0.09
All of the neoplastic cells were negative for EMA, CDX2 and TTF-1, and no evident tumor cell mucin production was seen on mucicarmine and DPAS staining.
Neg (negative) Gene_expression (negative) of CDX2 associated with cancer
9) Confidence 0.36 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2034570 Disease Relevance 1.45 Pain Relevance 0
Immunohistochemistry showed that the adenocarcinoma cells were diffusely positive for cytokeratin 20 (CK20) and caudal-type homeobox transcription factor-2 (CDX2) but negative for CK7, confirming the colonic phenotype.
Neg (negative) Gene_expression (positive) of CDX2 associated with adenocarcinoma
10) Confidence 0.18 Published 2008 Journal Pathol. Int. Section Abstract Doc Link 19067855 Disease Relevance 1.38 Pain Relevance 0.08

General Comments

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