INT156610

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.25
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBB) transport (HBB)
Anatomy Link Frequency
neuronal 1
HBB (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 92.76 High High
Nicotine 1 77.40 Quite High
abdominal pain 1 60.60 Quite High
fibrosis 5 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Parenteral administration 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 14 99.30 Very High Very High Very High
Thalassemia 187 97.92 Very High Very High Very High
Thrombocytopenia 3 72.48 Quite High
Abdominal Pain 1 60.60 Quite High
Anaemia 25 32.16 Quite Low
Iron Overload 33 18.24 Low Low
Infection 10 16.56 Low Low
Diabetes Mellitus 10 5.00 Very Low Very Low Very Low
Hypothyroidism 8 5.00 Very Low Very Low Very Low
Osteoporosis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These functional in vitro data demonstrate for the first time that HBB blocks neuronal nicotinic ACh receptors in the same concentration range as it inhibits muscarinic ACh receptors.
Negative_regulation (blocks) of HBB in neuronal
1) Confidence 0.37 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19070647 Disease Relevance 0.06 Pain Relevance 0.15
In homozygous beta-thalassemia, primary genetic modifiers, affecting the clinical severity of the disease, include genetic variants able to reduce the globin chain imbalance, therefore resulting in a milder form of thalassemia.
Negative_regulation (reduce) of globin chain associated with thalassemia and disease
2) Confidence 0.03 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 1.19 Pain Relevance 0

General Comments

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