INT156614

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.51
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A1) extracellular region (COL1A1) cytoplasm (COL1A1)
Anatomy Link Frequency
chondrocytes 2
macrophage 2
COL1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 17 93.08 High High
Osteoarthritis 90 91.64 High High
cytokine 87 89.64 High High
Inflammation 120 81.80 Quite High
Infliximab 20 80.24 Quite High
fibrosis 47 78.88 Quite High
Chronic pancreatitis 33 77.80 Quite High
COX2 28 68.40 Quite High
Inflammatory response 22 57.88 Quite High
Snapping jaw 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
Stress 238 100.00 Very High Very High Very High
Apoptosis 112 98.72 Very High Very High Very High
Primary Sclerosing Cholangitis 77 97.44 Very High Very High Very High
Osteoarthritis 102 91.64 High High
Liver Disease 86 87.24 High High
Sepsis 15 82.32 Quite High
INFLAMMATION 139 81.80 Quite High
Cirrhosis 102 79.36 Quite High
Pancreatitis 33 77.80 Quite High
Injury 109 52.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We compared the fluorescent staining and light microscopy results of both proteins within each disc to confirm fibronectin and collagen I expression.
Regulation (confirm) of Gene_expression (expression) of collagen I
1) Confidence 0.33 Published 2009 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 19070755 Disease Relevance 0 Pain Relevance 0
As fibrocartilaginous collagen type I and hyaline collagen type II expression are differentially regulated in chondrocytes [34], analyzing the collagen type II/type I expression ratios is informative of chondrogenic potential [51].
Regulation (regulated) of Gene_expression (expression) of collagen type I in chondrocytes
2) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.30 Pain Relevance 0.08
The same observation holds for COL1 expression in the early passages, but not for COL1 expression in the later passages.
Regulation (holds) of Gene_expression (expression) of COL1
3) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.21 Pain Relevance 0.03
The same observation holds for COL1 expression in the early passages, but not for COL1 expression in the later passages.
Regulation (holds) of Gene_expression (expression) of COL1
4) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.21 Pain Relevance 0.03
-induced effects on cell proliferation (Figure 4), ECM contraction (Figure 5b), and collagen type I gene expression (Figure 6b).
Regulation (effects) of Gene_expression (expression) of collagen type I gene
5) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.05 Pain Relevance 0.36
-tocopherol to rats undergoing this protocol resulted not only in a reduction of oxidative stress, lipid peroxidation and HNE, but also in decreased synthesis of both collagen type I and TGF ?
Regulation (resulted) of Gene_expression (synthesis) of collagen type I associated with stress
6) Confidence 0.07 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.60 Pain Relevance 0.15
The activation of NOX and intracellular generation of ROS have been involved in the up-regulation of collagen type I expression in HSC/MFs after engulfment by apoptotic bodies from dead hepatocytes [97], a finding similar to an earlier report showing that macrophage engulfment of apoptotic bodies resulted in increased transcription of TGF?
Regulation (regulation) of Gene_expression (expression) of collagen type I in macrophage associated with apoptosis
7) Confidence 0.07 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.39 Pain Relevance 0.06
Low-level expression of collagen1 and fibronectin was unaltered in PBMC following coculture (data not shown).
Regulation (unaltered) of Gene_expression (expression) of collagen1
8) Confidence 0.05 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.75 Pain Relevance 0.28

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