INT15663

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Context Info
Confidence 0.26
First Reported 1991
Last Reported 2003
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.10
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) plasma membrane (Drd2) signal transducer activity (Drd2)
Anatomy Link Frequency
neurons 2
brain 2
Drd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 7 100.00 Very High Very High Very High
withdrawal 5 99.32 Very High Very High Very High
Morphine 3 98.00 Very High Very High Very High
Opioid 3 97.60 Very High Very High Very High
substance P 8 95.88 Very High Very High Very High
addiction 1 93.56 High High
narcan 1 73.04 Quite High
dopamine receptor 1 64.84 Quite High
Nucleus accumbens 2 43.92 Quite Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Opiate Addiction 1 98.04 Very High Very High Very High
Urological Neuroanatomy 2 42.16 Quite Low
Substance Withdrawal Syndrome 1 31.76 Quite Low
Disease 1 5.00 Very Low Very Low Very Low
Movement Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we have investigated the effect of the heptapeptide fragment on the expression of the brain dopamine D2 receptor mRNA and on the withdrawal reaction, as well, in morphine-dependent rats.
Spec (investigated) Regulation (effect) of Transcription (expression) of dopamine D2 receptor in brain associated with dopamine, withdrawal and morphine
1) Confidence 0.26 Published 2003 Journal Peptides Section Abstract Doc Link 12576096 Disease Relevance 0.10 Pain Relevance 1.11
Haloperidol treatment did not modify the number of medium-sized enkephalinergic neurons expressing the D2 receptor mRNA.
Neg (not) Regulation (modify) of Transcription (expressing) of D2 receptor in neurons
2) Confidence 0.15 Published 1991 Journal Neuroscience Section Abstract Doc Link 1754061 Disease Relevance 0 Pain Relevance 0.14

General Comments

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