INT156632

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Context Info
Confidence 0.13
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prkaca, Scn10a) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) protein complex (Prkaca) transmembrane transport (Scn10a)
Anatomy Link Frequency
primary sensory neuron 1
Prkaca (Rattus norvegicus)
Scn10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 4 94.24 High High
sodium channel 2 75.00 Quite High
Kinase C 2 75.00 Quite High
intrathecal 1 65.08 Quite High
Inflammation 2 25.00 Low Low
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 5 95.84 Very High Very High Very High
INFLAMMATION 4 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrated that the functional regulation of the Na(V)1.8 mRNA by PKA and PKCvarepsilon in the primary sensory neuron is important for the development of the peripheral pro-nociceptive state induced by repetitive inflammatory stimuli and for the maintenance of the behavioral persistent hypernociception.
PKA Regulation (regulation) of Na(V)1.8 in primary sensory neuron associated with nociception and inflammatory stimuli
1) Confidence 0.13 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19073148 Disease Relevance 0.67 Pain Relevance 0.30

General Comments

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