INT156641

Context Info Confidence 0.07 First Reported 2007 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 3.19 Pain Relevance 0.90

cytosol (CNOT4) RNA binding (CNOT4) nucleus (CNOT4) ligase activity (CNOT4) cytoplasm (CNOT4)

Anatomy Link Frequency platelet 1 reticulum 1 CNOT4 (Homo sapiens)

Pain Link Frequency Relevance Heat cocaine 140 95.28 cINOD 7 94.24 cva 9 91.40 adenocard 2 69.92 addiction 5 61.52 Nicotine 18 5.00 Inflammation 10 5.00 Angina 6 5.00 antagonist 3 5.00 aspirin 3 5.00

Disease Link Frequency Relevance Heat Coagulation Disorder 9 98.40 Stress 168 97.20 Starvation 2 93.80 Stomach Cancer 1 92.88 Stroke 16 91.40 Hypoxia 41 90.16 Hemorrhage 1 89.44 Cancer 90 86.80 Apoptosis 50 78.20 INFLAMMATION 17 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The celecoxib-mediated up-regulation of S100P was suppressed by the transfection of cells with small interfering RNA for activating transcription factor 4 (ATF4), a transcription factor involved in the endoplasmic reticulum stress response.

Positive_regulation (activating) of factor 4 in reticulum associated with stress

1) Confidence 0.07 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19073601 Disease Relevance 0.79 Pain Relevance 0.32

-phosphorylation the translation of most mRNAs is inhibited, but paradoxically the translation of activating transcription factor 4 (ATF4) is increased.

Positive_regulation (activating) of factor 4

2) Confidence 0.05 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.92 Pain Relevance 0

Relative to placebo administration there was a statistically significant increase in platelet factor 4, ?

Positive_regulation (increase) of factor 4 in platelet

3) Confidence 0.04 Published 2007 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2042971 Disease Relevance 0.65 Pain Relevance 0.52

phosphorylation promotes the induction of activating transcription factor 4 (ATF4) through a mechanism that relies upon unique features in its 5' untranslated region [54].

Positive_regulation (induction) of factor 4

4) Confidence 0.02 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.42 Pain Relevance 0.03

phosphorylation promotes the induction of activating transcription factor 4 (ATF4) through a mechanism that relies upon unique features in its 5' untranslated region [54].

Positive_regulation (activating) of factor 4

5) Confidence 0.02 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.41 Pain Relevance 0.03

General Comments

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