INT156648

Context Info Confidence 0.42 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.79 Pain Relevance 0.32

nucleoplasm (ATF4) DNA binding (ATF4) microtubule organizing center (ATF4) cytoplasm (ATF4) nucleus (ATF4) cytoskeleton (ATF4)

Anatomy Link Frequency reticulum 2 ATF4 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 5 94.24

Disease Link Frequency Relevance Heat Stress 2 97.44 Stomach Cancer 1 92.88 Cancer 3 86.80 Apoptosis 4 78.20 INFLAMMATION 2 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The celecoxib-mediated up-regulation of S100P was suppressed by the transfection of cells with small interfering RNA for activating transcription factor 4 (ATF4), a transcription factor involved in the endoplasmic reticulum stress response.

Positive_regulation (activating) of Transcription (transcription) of ATF4 in reticulum associated with stress

1) Confidence 0.42 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19073601 Disease Relevance 0.79 Pain Relevance 0.32

General Comments

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