INT156649

Context Info Confidence 0.69 First Reported 2004 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 5 Disease Relevance 2.79 Pain Relevance 0.88

nucleoplasm (ATF4) DNA binding (ATF4) microtubule organizing center (ATF4) cytoplasm (ATF4) nucleus (ATF4) cytoskeleton (ATF4)

Anatomy Link Frequency reticulum 2 ATF4 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 15 98.72 cINOD 18 98.04 Inflammation 15 97.44 adenocard 3 36.64 COX2 3 5.00 metalloproteinase 3 5.00 Glutamate 3 5.00

Disease Link Frequency Relevance Heat Hypoxia 5 99.92 INFLAMMATION 18 97.44 Stress 7 97.44 Stomach Cancer 7 95.00 Colon Cancer 120 94.24 Cancer 31 88.92 Apoptosis 38 80.32 Leukemia 9 77.28 Adhesions 12 68.04 Metastasis 3 64.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Elevated expression of ATF4 is associated with resistance to current chemotherapeutic drugs including DNA-interactive and damaging agents, nonsteroidal anti-inflammatory drugs and proteasome inhibitors.

Positive_regulation (Elevated) of Gene_expression (expression) of ATF4 associated with inflammation and cinod

1) Confidence 0.69 Published 2009 Journal Cell Cycle Section Abstract Doc Link 19887912 Disease Relevance 0.86 Pain Relevance 0.10

The celecoxib-mediated up-regulation of S100P was suppressed by the transfection of cells with small interfering RNA for activating transcription factor 4 (ATF4), a transcription factor involved in the endoplasmic reticulum stress response.

Positive_regulation (transfection) of Gene_expression (transfection) of ATF4 in reticulum associated with stress

2) Confidence 0.39 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19073601 Disease Relevance 0.81 Pain Relevance 0.33

Indeed, curcumin was found to upregulate expression of ATF4 at the early time points, consistent with its role as an initiator of the curcumin effect through gene transcription modulation.

Positive_regulation (upregulate) of Gene_expression (expression) of ATF4

3) Confidence 0.37 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.21 Pain Relevance 0

Induction of ATF4 expression at the early time points is followed by induction of expression of ASNS at the same and later time points.

Positive_regulation (Induction) of Gene_expression (expression) of ATF4

4) Confidence 0.37 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.15 Pain Relevance 0

For example, expression of ASNS, ATF4 and MTHFD2 was upregulated by sulindac and expression of BUB1B and PDCD2 was downregulated by aspirin.

Positive_regulation (upregulated) of Gene_expression (expression) of ATF4 associated with aspirin

5) Confidence 0.27 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.76 Pain Relevance 0.46

General Comments

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