INT156649
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Elevated expression of ATF4 is associated with resistance to current chemotherapeutic drugs including DNA-interactive and damaging agents, nonsteroidal anti-inflammatory drugs and proteasome inhibitors. | |||||||||||||||
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The celecoxib-mediated up-regulation of S100P was suppressed by the transfection of cells with small interfering RNA for activating transcription factor 4 (ATF4), a transcription factor involved in the endoplasmic reticulum stress response. | |||||||||||||||
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Indeed, curcumin was found to upregulate expression of ATF4 at the early time points, consistent with its role as an initiator of the curcumin effect through gene transcription modulation. | |||||||||||||||
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Induction of ATF4 expression at the early time points is followed by induction of expression of ASNS at the same and later time points. | |||||||||||||||
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For example, expression of ASNS, ATF4 and MTHFD2 was upregulated by sulindac and expression of BUB1B and PDCD2 was downregulated by aspirin. | |||||||||||||||
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General Comments
This test has worked.