INT156649

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.79
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF4) DNA binding (ATF4) microtubule organizing center (ATF4)
cytoplasm (ATF4) nucleus (ATF4) cytoskeleton (ATF4)
Anatomy Link Frequency
reticulum 2
ATF4 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 15 98.72 Very High Very High Very High
cINOD 18 98.04 Very High Very High Very High
Inflammation 15 97.44 Very High Very High Very High
adenocard 3 36.64 Quite Low
COX2 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 5 99.92 Very High Very High Very High
INFLAMMATION 18 97.44 Very High Very High Very High
Stress 7 97.44 Very High Very High Very High
Stomach Cancer 7 95.00 High High
Colon Cancer 120 94.24 High High
Cancer 31 88.92 High High
Apoptosis 38 80.32 Quite High
Leukemia 9 77.28 Quite High
Adhesions 12 68.04 Quite High
Metastasis 3 64.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated expression of ATF4 is associated with resistance to current chemotherapeutic drugs including DNA-interactive and damaging agents, nonsteroidal anti-inflammatory drugs and proteasome inhibitors.
Positive_regulation (Elevated) of Gene_expression (expression) of ATF4 associated with inflammation and cinod
1) Confidence 0.69 Published 2009 Journal Cell Cycle Section Abstract Doc Link 19887912 Disease Relevance 0.86 Pain Relevance 0.10
The celecoxib-mediated up-regulation of S100P was suppressed by the transfection of cells with small interfering RNA for activating transcription factor 4 (ATF4), a transcription factor involved in the endoplasmic reticulum stress response.
Positive_regulation (transfection) of Gene_expression (transfection) of ATF4 in reticulum associated with stress
2) Confidence 0.39 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19073601 Disease Relevance 0.81 Pain Relevance 0.33
Indeed, curcumin was found to upregulate expression of ATF4 at the early time points, consistent with its role as an initiator of the curcumin effect through gene transcription modulation.
Positive_regulation (upregulate) of Gene_expression (expression) of ATF4
3) Confidence 0.37 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.21 Pain Relevance 0
Induction of ATF4 expression at the early time points is followed by induction of expression of ASNS at the same and later time points.
Positive_regulation (Induction) of Gene_expression (expression) of ATF4
4) Confidence 0.37 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.15 Pain Relevance 0
For example, expression of ASNS, ATF4 and MTHFD2 was upregulated by sulindac and expression of BUB1B and PDCD2 was downregulated by aspirin.
Positive_regulation (upregulated) of Gene_expression (expression) of ATF4 associated with aspirin
5) Confidence 0.27 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.76 Pain Relevance 0.46

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox