INT156666

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.94
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
sensory neurons 8
liver 4
plasma 2
neurons 2
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 20 100.00 Very High Very High Very High
qutenza 16 99.98 Very High Very High Very High
Kinase C 5 98.16 Very High Very High Very High
Hippocampus 8 95.88 Very High Very High Very High
imagery 12 82.52 Quite High
Inflammation 12 82.24 Quite High
Bioavailability 1 63.36 Quite High
depression 1 60.12 Quite High
Eae 6 57.68 Quite High
Somatostatin 92 31.56 Quite Low
Disease Link Frequency Relevance Heat
Acromegaly 94 100.00 Very High Very High Very High
Neurodegenerative Disease 39 99.98 Very High Very High Very High
Death 84 99.76 Very High Very High Very High
Disease 162 98.84 Very High Very High Very High
Hyperinsulinism 9 98.14 Very High Very High Very High
Targeted Disruption 10 97.12 Very High Very High Very High
Hypoglycemia 13 97.06 Very High Very High Very High
Apoptosis 155 95.56 Very High Very High Very High
Insulin Resistance 24 92.08 High High
Syndrome 37 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GH mediates its effects largely through the increased secretion of insulin-like growth factor 1 (IGF-1) in target tissues including the liver.
Positive_regulation (increased) of Localization (secretion) of insulin-like growth factor 1 in liver
1) Confidence 0.62 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.95 Pain Relevance 0
Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I and IGF-I mRNA in various organs via increased calcitonin gene-related peptide (CGRP) release in mice.
Positive_regulation (increased) of Localization (release) of IGF-I in sensory neurons associated with qutenza and calcitonin gene-related peptide
2) Confidence 0.49 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.40 Pain Relevance 0.41
Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I and IGF-I mRNA in various organs via increased calcitonin gene-related peptide (CGRP) release in mice.
Positive_regulation (increases) of Localization (release) of IGF-I in sensory neurons associated with qutenza and calcitonin gene-related peptide
3) Confidence 0.49 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.40 Pain Relevance 0.41
Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I and IGF-I mRNA in various organs via increased calcitonin gene-related peptide (CGRP) release in mice.
Positive_regulation (increases) of Localization (release) of IGF-I in sensory neurons associated with qutenza and calcitonin gene-related peptide
4) Confidence 0.49 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.40 Pain Relevance 0.41
Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I and IGF-I mRNA in various organs via increased calcitonin gene-related peptide (CGRP) release in mice.
Positive_regulation (increased) of Localization (release) of IGF-I in sensory neurons associated with qutenza and calcitonin gene-related peptide
5) Confidence 0.49 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.40 Pain Relevance 0.41
Neurogenesis triggered by IGF-1 and GH, i.e., an increased number of neurons, seems more unlikely as neurogenesis is restricted to few brain regions such as the hippocampus.
Positive_regulation (increased) of Localization (triggered) of IGF-1 in neurons associated with hippocampus and neurodegenerative disease
6) Confidence 0.49 Published 2008 Journal Pituitary Section Body Doc Link PMC2712618 Disease Relevance 0.61 Pain Relevance 0.20
As discussed above, epidemiological studies have clearly demonstrated that controlling GH and IGF-I secretion is the most significant determinant of restoring survival in patients with acromegaly The main goal of treatment of acromegaly is therefore to achieve GH levels of less than 1 ?
Positive_regulation (achieve) of Localization (secretion) of IGF-I associated with acromegaly
7) Confidence 0.47 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.75 Pain Relevance 0
Circulating IGF-I reflects GH secretion rate and serum concentrations of IGF-I are elevated in all patients with active disease (Melmed 2006).
Positive_regulation (elevated) of Localization (secretion) of IGF-I associated with disease
8) Confidence 0.47 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.51 Pain Relevance 0
Because of this fact, in patients with insulinoma, a condition characterized by marked hyperinsulinemia, downregulation of insulin receptors induced by elevated plasma insulin was associated with increased abundance of hybrid insulin/IGF-I receptors.[26]
Positive_regulation (increased) of Localization (abundance) of IGF-I in plasma associated with hypoglycemia and hyperinsulinism
9) Confidence 0.46 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772007 Disease Relevance 0.40 Pain Relevance 0.03
GH mediates its effects largely through the increased secretion of insulin-like growth factor 1 (IGF-1) in target tissues including the liver.
Positive_regulation (increased) of Localization (secretion) of IGF-1 in liver
10) Confidence 0.45 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1698946 Disease Relevance 0.95 Pain Relevance 0
The relevance of trophic support, mainly NGF and IGF-1, and other growth factor signaling through trk receptors and activation of PI3K/Akt and PKC, is also linked to the key role played by GSK-3?
Positive_regulation (through) of Localization (relevance) of IGF-1 associated with kinase c
11) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.15 Pain Relevance 0.08

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