INT156667

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.88
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gh, Igf1) extracellular region (Gh, Igf1) cytosol (Gh)
signal transduction (Gh) mitochondrion (Gh) plasma membrane (Gh)
Anatomy Link Frequency
liver 2
Gh (Mus musculus)
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 8 85.52 High High
Calcitonin gene-related peptide 10 78.32 Quite High
Somatostatin 22 76.84 Quite High
cytokine 9 33.72 Quite Low
MU agonist 1 33.16 Quite Low
antagonist 10 5.00 Very Low Very Low Very Low
Dopamine 9 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hematological Disease 10 100.00 Very High Very High Very High
Hyperplasia 2 94.12 High High
Cancer 52 93.04 High High
Osteoporosis 4 87.76 High High
Disease 9 83.52 Quite High
Injury 4 66.16 Quite High
Apoptosis 11 63.84 Quite High
Acromegaly 27 50.00 Quite Low
Lung Cancer 16 50.00 Quite Low
Appetite Loss 1 49.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GH stimulates the production of IGF-I in many organs.
GH Positive_regulation (stimulates) of Gene_expression (production) of IGF-I
1) Confidence 0.28 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0 Pain Relevance 0.08
Although it is well known that growth hormone (GH) increases serum IGF-I levels by stimulating the hepatic production, little is known about the mechanism by which local production of IGF-I in individual tissues is regulated.
growth hormone Positive_regulation (increases) of Gene_expression (levels) of IGF-I
2) Confidence 0.23 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.22 Pain Relevance 0.24
Although it is well known that growth hormone (GH) increases serum IGF-I levels by stimulating the hepatic production, little is known about the mechanism by which local production of IGF-I in individual tissues is regulated.
GH Positive_regulation (increases) of Gene_expression (levels) of IGF-I
3) Confidence 0.23 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.22 Pain Relevance 0.24
It was previously demonstrated that growth hormone mediates at least some of its effects on hematopoiesis through production of IGF-1 [9].
growth hormone Positive_regulation (mediates) of Gene_expression (production) of IGF-1 associated with hematological disease
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886847 Disease Relevance 0.26 Pain Relevance 0
Generally, growth hormone exposure induces hepatic IGF-I production by increasing transcription of IGF-I mRNA (41).
growth hormone Positive_regulation (induces) of Gene_expression (production) of IGF-I
5) Confidence 0.03 Published 2007 Journal Pharm Res Section Body Doc Link PMC2063566 Disease Relevance 0 Pain Relevance 0
GH stimulates the biosynthesis of IGF-1 in liver and in other organs and tissues and an autocrine or paracrine GH/IGF-1 system have been evidenced in lymphoid tissues, capable of influencing lymphopoiesis and immune function [19-21].
GH Positive_regulation (stimulates) of Gene_expression (biosynthesis) of IGF-1 in liver
6) Confidence 0.00 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2910689 Disease Relevance 0.18 Pain Relevance 0

General Comments

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