INT156668

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.07
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gh, Igf1) extracellular region (Gh, Igf1) cytosol (Gh)
signal transduction (Gh) mitochondrion (Gh) plasma membrane (Gh)
Gh (Mus musculus)
Igf1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 8 84.96 Quite High
Inflammation 68 83.64 Quite High
Calcitonin gene-related peptide 10 77.76 Quite High
cytokine 100 50.00 Quite Low
Somatostatin 13 21.20 Low Low
Serotonin 1 17.48 Low Low
rheumatoid arthritis 20 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoid 20 99.58 Very High Very High Very High
Hypertrophy 2 95.08 Very High Very High Very High
Hyperplasia 11 94.12 High High
Body Weight 4 92.80 High High
Disease 44 84.00 Quite High
INFLAMMATION 62 83.64 Quite High
Metastasis 15 75.84 Quite High
Injury 2 65.60 Quite High
Apoptosis 2 63.28 Quite High
Hepatotoxicity 2 58.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although it is well known that growth hormone (GH) increases serum IGF-I levels by stimulating the hepatic production, little is known about the mechanism by which local production of IGF-I in individual tissues is regulated.
growth hormone Positive_regulation (increases) of IGF-I
1) Confidence 0.22 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.22 Pain Relevance 0.24
Although it is well known that growth hormone (GH) increases serum IGF-I levels by stimulating the hepatic production, little is known about the mechanism by which local production of IGF-I in individual tissues is regulated.
GH Positive_regulation (increases) of IGF-I
2) Confidence 0.22 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 19075656 Disease Relevance 0.22 Pain Relevance 0.24
After removal of the carcinoid tumor in patient 3, GHRH, GH, and IGF-I concentrations remained elevated, and therefore he was also treated with the long-acting repeatable octreotide (20 mg/4 weeks).
GH Positive_regulation (elevated) of IGF-I associated with carcinoid
3) Confidence 0.15 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.24 Pain Relevance 0
Growth promotion by GH is dependent on the induction of insulin-like growth factor-1 (IGF-1) by GH, whereas SOCS2-deficient mice do not exhibit an increase in serum IGF-1.
GH Positive_regulation (induction) of IGF-1
4) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.69 Pain Relevance 0.04
Growth promotion by GH is dependent on the induction of insulin-like growth factor-1 (IGF-1) by GH, whereas SOCS2-deficient mice do not exhibit an increase in serum IGF-1.
GH Positive_regulation (induction) of insulin-like growth factor-1
5) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.69 Pain Relevance 0.04

General Comments

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