INT156671

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 22
Total Number 31
Disease Relevance 23.32
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vcsa1)
Anatomy Link Frequency
bladder 6
ureter 4
urethra 4
smooth muscle 2
spinal 1
Vcsa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 427 97.80 Very High Very High Very High
Enkephalin 20 97.76 Very High Very High Very High
substance P 20 97.00 Very High Very High Very High
agonist 10 96.16 Very High Very High Very High
antidepressant 10 92.32 High High
Pain 10 91.24 High High
Inflammatory response 50 83.44 Quite High
Analgesic 1 70.64 Quite High
ganglionectomy 30 63.08 Quite High
Spinal cord 90 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 2 2880 99.96 Very High Very High Very High
Diabetes Mellitus 1180 99.68 Very High Very High Very High
Aging 80 99.62 Very High Very High Very High
Stress Incontinence 40 99.32 Very High Very High Very High
Disorders Of The Lacrimal System 10 98.20 Very High Very High Very High
INFLAMMATION 455 97.80 Very High Very High Very High
Hypersensitivity 42 96.48 Very High Very High Very High
Pain 10 91.24 High High
Salivary Gland Disease 110 90.00 High High
Adhesions 90 86.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The SMR1 protein product of the rat Vcsa1 gene is cleaved into at least two biologically active peptides, sialorphin (QHNPR) and SGP-T (TDIFEGG) (Figure 3).
Gene_expression (product) of SMR1 protein
1) Confidence 0.75 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2955637 Disease Relevance 0.16 Pain Relevance 0
Vcsa1 expression is hormonally regulated by androgens [33,36], and the expression of opiorphin family genes may be similarly regulated [37].


Gene_expression (expression) of Vcsa1
2) Confidence 0.75 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2955637 Disease Relevance 0.27 Pain Relevance 0.17
SGP-T was identified as the carboxyl terminal of SMR1, a 146-amino acid, multipotent prohormone product of the VCSa1 (variable coding sequence A1) gene [18], which is also identified as RATSMR1A, Smr1, SMR1 protein and VCS-alpha 1.
Gene_expression (product) of SMR1
3) Confidence 0.75 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2955637 Disease Relevance 0.57 Pain Relevance 0.11
With the absence of the VCSA subgroup of genes in non-rodent mammals, sialorphin and SGP-T may not be present, although homologues of these peptides are encoded by VCSB genes.
Neg (not) Gene_expression (present) of sialorphin
4) Confidence 0.65 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2955637 Disease Relevance 0.15 Pain Relevance 0.11
The Vcsa1 gene that encodes the rat SMR1 protein is a member of the variable coding sequence multigene family, which share a common gene structure but exhibit extensive sequence variation in the coding region of the genes [25].
Gene_expression (encodes) of Vcsa1
5) Confidence 0.65 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2955637 Disease Relevance 0.26 Pain Relevance 0
The SMR1 protein product of the rat Vcsa1 gene is cleaved into at least two biologically active peptides, sialorphin (QHNPR) and SGP-T (TDIFEGG) (Figure 3).
Gene_expression (product) of Vcsa1
6) Confidence 0.65 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2955637 Disease Relevance 0.16 Pain Relevance 0
Recent studies have shown that SMR1 is secreted into saliva in response to intraperitoneal administration of ?
Gene_expression (intraperitoneal) of SMR1 in saliva
7) Confidence 0.65 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2955637 Disease Relevance 0.56 Pain Relevance 0.11
The Vcsa1 gene that encodes the rat SMR1 protein is a member of the variable coding sequence multigene family, which share a common gene structure but exhibit extensive sequence variation in the coding region of the genes [25].
Gene_expression (encodes) of SMR1 protein
8) Confidence 0.65 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2955637 Disease Relevance 0.26 Pain Relevance 0
Although there is less expression of Vcsa1 in the bladder, RNA extracted from the bladder also demonstrated a significant decrease in Vcsa1 expression associated with diabetes of approximately 5-fold.
Gene_expression (expression) of Vcsa1 in bladder associated with diabetes mellitus
9) Confidence 0.64 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.06 Pain Relevance 0
We have recently demonstrated that both gene transfer of Vcsa1 and sialorphin can improve erectile function in the aging rat[2263] suggesting that they play a direct role in the regulating corporal smooth muscle tone.
Gene_expression (transfer) of sialorphin in smooth muscle associated with aging
10) Confidence 0.64 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.48 Pain Relevance 0.15
In an aging rat model for ED, Vcsa1 expression is down-regulated.[22] We have recently shown that treating these rats to restore erectile function using gene therapy (hMaxiK) or tadalifil reverses the down-regulation of Vcsa1.
Gene_expression (expression) of Vcsa1 associated with reprotox - general 2 and aging
11) Confidence 0.64 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.49 Pain Relevance 0
We confirmed this observation using quantitative RT-PCR to measure Vcsa1 expression in non-diabetic and one-week and two-month diabetic rats.[22] In addition to corporal tissue we also looked at Vcsa1 gene expression in the bladder, urethra, and ureter.
Gene_expression (expression) of Vcsa1 gene in ureter associated with stress incontinence and diabetes mellitus
12) Confidence 0.64 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.07 Pain Relevance 0
Quantitative RT-PCR demonstrated that after one week of diabetes, there was no significant change in the expression of Vcsa1 compared with non-diabetic animals in bladder, urethra, and ureter, and a slight (50% decrease) change in expression of Vcsa1 in the corpora.
Gene_expression (expression) of Vcsa1 in urethra associated with stress incontinence and diabetes mellitus
13) Confidence 0.64 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.94 Pain Relevance 0
Quantitative RT-PCR demonstrated that after one week of diabetes, there was no significant change in the expression of Vcsa1 compared with non-diabetic animals in bladder, urethra, and ureter, and a slight (50% decrease) change in expression of Vcsa1 in the corpora.
Gene_expression (expression) of Vcsa1 in urethra associated with stress incontinence and diabetes mellitus
14) Confidence 0.64 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.95 Pain Relevance 0
However, after two months, there was an even greater decrease in Vcsa1 expression in the corpora, where there was a 10-fold decrease in transcript.
Gene_expression (expression) of Vcsa1
15) Confidence 0.64 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.99 Pain Relevance 0
Although there is less expression of Vcsa1 in the bladder, RNA extracted from the bladder also demonstrated a significant decrease in Vcsa1 expression associated with diabetes of approximately 5-fold.
Gene_expression (expression) of Vcsa1 in bladder associated with diabetes mellitus
16) Confidence 0.64 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.05 Pain Relevance 0
We confirmed this observation using quantitative RT-PCR to measure Vcsa1 expression in non-diabetic and one-week and two-month diabetic rats.[22] In addition to corporal tissue we also looked at Vcsa1 gene expression in the bladder, urethra, and ureter.
Gene_expression (expression) of Vcsa1 in ureter associated with stress incontinence and diabetes mellitus
17) Confidence 0.64 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.05 Pain Relevance 0.08
We have recently demonstrated that both gene transfer of Vcsa1 and sialorphin can improve erectile function in the aging rat[2263] suggesting that they play a direct role in the regulating corporal smooth muscle tone.
Gene_expression (transfer) of Vcsa1 in smooth muscle associated with aging
18) Confidence 0.64 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 0.48 Pain Relevance 0.15
Overall our paper demonstrated a correlation between decreased expression of Vcsa1 in the corpora and erectile function in at least three models of ED.[22]
Gene_expression (expression) of Vcsa1 associated with reprotox - general 2
19) Confidence 0.64 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.32 Pain Relevance 0
The biologically active peptide products of SMR1 are considered and the mechanism of action and structure-activity relationships of the anti-inflammatory submandibular gland peptide-T and its derivatives are discussed.
Gene_expression (products) of SMR1 in submandibular gland associated with inflammation
20) Confidence 0.60 Published 2007 Journal Recent patents on inflammation & allergy drug discovery Section Abstract Doc Link 19075974 Disease Relevance 0.58 Pain Relevance 0.28

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