INT156676

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 5.78
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Rtn4) endoplasmic reticulum (Rtn4) plasma membrane (Rtn4)
protein complex (Rtn4) cytoplasm (Rtn4)
Anatomy Link Frequency
oligodendrocytes 6
spinal cord 1
optic nerve 1
Rtn4 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 184 99.84 Very High Very High Very High
Spinal cord 82 98.60 Very High Very High Very High
Peripheral nervous system 21 70.24 Quite High
Sciatic nerve 12 59.76 Quite High
Pain 1 46.64 Quite Low
Eae 1 26.56 Quite Low
cINOD 18 5.00 Very Low Very Low Very Low
Kinase C 15 5.00 Very Low Very Low Very Low
cva 15 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 246 99.92 Very High Very High Very High
Targeted Disruption 213 99.72 Very High Very High Very High
Frailty 13 98.60 Very High Very High Very High
Cicatrix 12 94.72 High High
Cognitive Disorder 1 90.80 High High
Volume Depletion And Dehydration 12 89.76 High High
Optic Nerve Injuries 45 83.08 Quite High
Glaucoma 15 80.72 Quite High
Spinal Cord Injury 48 77.24 Quite High
Paralysis 3 72.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, deletion of Nogo-A enhances regeneration following spinal cord injury.
Gene_expression (deletion) of Nogo in spinal cord associated with spinal cord
1) Confidence 0.65 Published 2009 Journal Genes Brain Behav. Section Abstract Doc Link 19077178 Disease Relevance 0.19 Pain Relevance 0.10
Increased expression of Nogo-A in RGCs after ON injury indicates that Nogo-A may play an inhibitory role in axonal regeneration after ON injury.
Gene_expression (expression) of Nogo associated with injury
2) Confidence 0.57 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.48 Pain Relevance 0.03
Nogo-A, Nogo-B, and Nogo-C are major protein species in oligodendrocytes and expressed in ON [1].
Gene_expression (expressed) of Nogo in oligodendrocytes
3) Confidence 0.50 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.72 Pain Relevance 0.27
Nogo-A, Nogo-B, and Nogo-C are major protein species in oligodendrocytes and expressed in ON [1].
Gene_expression (expressed) of Nogo in oligodendrocytes
4) Confidence 0.50 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.71 Pain Relevance 0.27
Expression of Nogo-A/B/C was calculated using image analysis software.
Gene_expression (Expression) of Nogo
5) Confidence 0.50 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.14 Pain Relevance 0
Expression of Nogo-A/B/C mRNA was demonstrated in the ON of young adult normal mice (Figure 1B).
Gene_expression (Expression) of Nogo
6) Confidence 0.49 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.21 Pain Relevance 0
Little or no expression of Nogo-A/B/C mRNA was observed in the ON of Nogo-A/B/C-knockout mice (Figure 1A).
Gene_expression (expression) of Nogo associated with targeted disruption
7) Confidence 0.49 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.16 Pain Relevance 0
Increased expression of Nogo-A in RGCs after ON injury indicates that Nogo-A may play an inhibitory role in axonal regeneration after ON injury.
Gene_expression (expression) of Nogo associated with injury
8) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.62 Pain Relevance 0.16
Stain of brown indicates positive expression of Nogo-A/B/C.
Gene_expression (expression) of Nogo
9) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.13 Pain Relevance 0
Little or no expression of Nogo-A/B/C mRNA was observed in the ON of Nogo-A/B/C-knockout mice (Figure 1A).
Gene_expression (expression) of Nogo associated with targeted disruption
10) Confidence 0.43 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.21 Pain Relevance 0
Nogo-A, Nogo-B, and Nogo-C are major protein species in oligodendrocytes and expressed in ON [1].
Gene_expression (expressed) of Nogo in oligodendrocytes
11) Confidence 0.38 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.72 Pain Relevance 0.27
Expression of Nogo-A/B/C was in the cytoplasm of oligodendrocytes of optic nerve which arrange like a line of pearl.
Gene_expression (Expression) of Nogo in optic nerve
12) Confidence 0.38 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.09 Pain Relevance 0
Positvie area of stain of Nogo-A/B/C expression of experimental group was 1.36±0.05x102?
Gene_expression (expression) of Nogo
13) Confidence 0.38 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2263011 Disease Relevance 0.15 Pain Relevance 0
NogoA is mainly expressed by CNS oligodendrocytes, whereas NogoB and NogoC are widely distributed outside the CNS.
Gene_expression (expressed) of NogoA in oligodendrocytes associated with central nervous system
14) Confidence 0.04 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.43 Pain Relevance 0.70
NogoA is mainly expressed by CNS oligodendrocytes, whereas NogoB and NogoC are widely distributed outside the CNS.
Gene_expression (distributed) of NogoC in oligodendrocytes associated with central nervous system
15) Confidence 0.04 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.41 Pain Relevance 0.68
NogoA is mainly expressed by CNS oligodendrocytes, whereas NogoB and NogoC are widely distributed outside the CNS.
Gene_expression (distributed) of NogoB in oligodendrocytes associated with central nervous system
16) Confidence 0.04 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.41 Pain Relevance 0.69

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