INT156677

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.25
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ednra) plasma membrane (Ednra) signal transducer activity (Ednra)
Anatomy Link Frequency
hypothalamus 4
Neurons 2
Ednra (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 49 100.00 Very High Very High Very High
electroacupuncture 16 99.96 Very High Very High Very High
analgesia 6 99.84 Very High Very High Very High
bradykinin 20 99.22 Very High Very High Very High
tail-flick 2 94.88 High High
Analgesic 6 93.04 High High
Pain threshold 2 86.44 High High
qutenza 94 85.68 High High
Calcitonin gene-related peptide 41 59.68 Quite High
dorsal root ganglion 44 10.08 Low Low
Disease Link Frequency Relevance Heat
Body Weight 2 99.04 Very High Very High Very High
Pain 11 86.44 High High
Disease 4 16.40 Low Low
Ganglion Cysts 46 10.08 Low Low
Nociception 14 5.00 Very Low Very Low Very Low
Hyperalgesia 10 5.00 Very Low Very Low Very Low
Neuropathic Pain 8 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of ET-receptor antagonists
Regulation (Effects) of Gene_expression (antagonists) of ET-receptor associated with antagonist
1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0 Pain Relevance 0.19
The ratio of ETA and ETBR expression was determined by 125I-ET-1 saturation binding analysis using ET-1 (1 ?
Regulation (ratio) of Gene_expression (expression) of ETA
2) Confidence 0.06 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0
Neurons cultured for longer rarely responded to ET-1, but did respond to bradykinin, suggesting that in cultured DRGs the expression of ET receptor subtypes might be down regulated or that there is an impairment in the efficiency of coupling to downstream signaling cascades.
Spec (might) Regulation (regulated) of Gene_expression (expression) of ET receptor in Neurons associated with bradykinin
3) Confidence 0.06 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0.50
In this study, we hypothesized that the expression of the AChET gene in the hypothalamus modulates EA analgesia in rats.
Regulation (modulates) of Gene_expression (expression) of AChET in hypothalamus associated with electroacupuncture and analgesia
4) Confidence 0.05 Published 2009 Journal Genes Brain Behav. Section Abstract Doc Link 19077179 Disease Relevance 0.07 Pain Relevance 0.62
Furthermore, expression of the AChET in the hypothalamus did not affect body core temperature, body weight, motor function or learning and memory ability.
Neg (not) Regulation (affect) of Gene_expression (expression) of AChET in hypothalamus associated with body weight
5) Confidence 0.05 Published 2009 Journal Genes Brain Behav. Section Abstract Doc Link 19077179 Disease Relevance 0.19 Pain Relevance 0.74

General Comments

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