INT1567

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Context Info
Confidence 0.47
First Reported 1979
Last Reported 1992
Negated 0
Speculated 2
Reported most in Abstract
Documents 10
Total Number 13
Disease Relevance 0.24
Pain Relevance 9.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TRIM13) endoplasmic reticulum (TRIM13) intracellular (TRIM13)
ligase activity (TRIM13) cytoplasm (TRIM13) signal transducer activity (TRIM13)
Anatomy Link Frequency
plasma 1
monocytes 1
cerebral cortex 1
NG108-15 1
T lymphocytes 1
TRIM13 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 34 100.00 Very High Very High Very High
Opioid 32 100.00 Very High Very High Very High
narcan 13 100.00 Very High Very High Very High
agonist 13 100.00 Very High Very High Very High
Morphine 8 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
opiate 29 99.40 Very High Very High Very High
cerebral cortex 6 98.88 Very High Very High Very High
Immobilon 9 98.28 Very High Very High Very High
antagonist 1 95.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Psychosis 1 88.72 High High
Glioma 2 75.00 Quite High
Neuroblastoma 2 75.00 Quite High
Pheochromocytoma 2 25.00 Low Low
Malignant Neoplastic Disease 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both treatments also eliminated the ability of low morphine concentrations (less than 1 nM) to inhibit 3H-D-Ala2-D-Leu5-enkephalin binding and of low D-Ala2-D-Leu5-enkephalin concentrations (less than 1 nM) to inhibit [3H]dihydromorphine binding.
Leu5 Binding (binding) of associated with enkephalin and morphine
1) Confidence 0.47 Published 1984 Journal Mol. Pharmacol. Section Abstract Doc Link 6323950 Disease Relevance 0 Pain Relevance 1.09
IC50 values of D-Ala2-D-Leu5-enkephalin's competition for [3H]diprenorphine binding to intact cells increased 19.6-fold after etorphine treatment for 90 min, while naloxone IC50 values remained unaltered.
Leu5 Binding (binding) of associated with narcan, enkephalin and immobilon
2) Confidence 0.47 Published 1983 Journal Mol. Pharmacol. Section Abstract Doc Link 6314114 Disease Relevance 0.15 Pain Relevance 0.90
Similarly, morphine (1 nM) inhibited the higher-affinity binding of 3H-D-Ala2-D-Leu5-enkephalin to a greater extent than its lower-affinity binding component, consistent with a common high-affinity binding site for opiates and enkephalins.
Leu5 Binding (binding) of associated with opiate, enkephalin and morphine
3) Confidence 0.47 Published 1984 Journal Mol. Pharmacol. Section Abstract Doc Link 6323950 Disease Relevance 0 Pain Relevance 0.87
Human mononuclear cells (B and T lymphocytes and monocytes) were examined for their ability to bind 3H-naloxone, a mu opioid ligand, and 3H-D-Ala2-D-Leu5-enkephalin, a delta opioid ligand.
Leu5 Spec (examined) Binding (bind) of in T lymphocytes associated with narcan, enkephalin and opioid
4) Confidence 0.47 Published 1985 Journal J Clin Lab Immunol Section Abstract Doc Link 2993625 Disease Relevance 0 Pain Relevance 0.68
Displacement curve analyses demonstrated that GTP and its nonhydrolyzable analog, GPP(NH)P, inhibited the binding of [3H]dihydromorphine (mu agonist), [3H]D-Ala2-D-Leu5-enkephalin (delta agonist), and [3H]ethylketocyclazocine (general agonist) but not [3H]diprenorphine (general antagonist).
Leu5 Binding (binding) of associated with antagonist, agonist and enkephalin
5) Confidence 0.47 Published 1985 Journal Brain Res. Bull. Section Abstract Doc Link 2988712 Disease Relevance 0 Pain Relevance 0.41
We studied the binding of [3H]D-Ala2-D-Leu5-enkephalin ([3H]DADLE) and [3H] diprenorphine to crude plasma membrane fraction obtained from the bovine adrenal medulla (bovine adrenal medullary membranes) in order to characterize adrenal medullary opioid receptors.
Leu5 Binding (binding) of in plasma associated with medulla, opioid receptor and enkephalin
6) Confidence 0.47 Published 1987 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 2822499 Disease Relevance 0 Pain Relevance 0.34
Based on inhibition of cross-linking, we calculated an affinity of [D-Ala2,D-Leu5]enkephalin binding to the 25-kDa and (Kd = 6 nM) that is similar to that reported for [D-Ala2,D-Leu5]enkephalin binding to NG108-15 membranes; this affinity decreased approximately 10-fold in the presence of Na+/guanyl-5'-yl imidodiphosphate.
Leu5 Binding (binding) of in NG108-15 associated with enkephalin
7) Confidence 0.36 Published 1992 Journal J. Biol. Chem. Section Abstract Doc Link 1320002 Disease Relevance 0 Pain Relevance 0.98
D-Ala2-Leu5-enkephalin (DALA) was elongated with the methyl ester of melphalan (Mel), a nitrogen mustard on the C-terminus.
Leu5 Binding (elongated) of associated with enkephalin
8) Confidence 0.36 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319899 Disease Relevance 0 Pain Relevance 0.81
The extent of maximum inhibition of specific [125I]beta h-EP binding by either levorphanol, morphine, naloxone, dynorphin A (1-13) or D-Ala2-D-Leu5-enkephalin was similar to each other and remained partial (60-70%).
Leu5 Binding (binding) of associated with dynorphin, narcan, enkephalin and morphine
9) Confidence 0.35 Published 1986 Journal Regul. Pept. Section Abstract Doc Link 2947271 Disease Relevance 0 Pain Relevance 0.56
By displacing mu and delta interactions with morphine and D-Ala2, D-Leu5-enkephalin (DADL) respectively we have visualized selective receptors for 3H-EKC and 3H-bremazocine.
Leu5 Binding (interactions) of associated with enkephalin and morphine
10) Confidence 0.35 Published 1982 Journal Life Sci. Section Abstract Doc Link 6128654 Disease Relevance 0 Pain Relevance 0.75
In order to obtain information on the possible functions of endogenous opiates in the primate cerebral cortex, we assessed the distribution of mu-like opiate receptors (which selectively bind 3H-labeled naloxone) and delta-like opiate receptors (which selectively bind 3H-labeled D-Ala2, D-Leu5-enkephalin) throughout the cerebral cortex of the rhesus monkey.
Leu5 Binding (bind) of in cerebral cortex associated with narcan, enkephalin, opiate and cerebral cortex
11) Confidence 0.35 Published 1981 Journal Science Section Abstract Doc Link 6258227 Disease Relevance 0 Pain Relevance 0.87
Human mononuclear cells (B and T lymphocytes and monocytes) were examined for their ability to bind 3H-naloxone, a mu opioid ligand, and 3H-D-Ala2-D-Leu5-enkephalin, a delta opioid ligand.
Leu5 Spec (examined) Binding (bind) of in monocytes associated with narcan, enkephalin and opioid
12) Confidence 0.16 Published 1985 Journal J Clin Lab Immunol Section Abstract Doc Link 2993625 Disease Relevance 0 Pain Relevance 0.68
Pharmacological and immunological characterization of the Leu5 analogue of human beta-endorphin.
Leu5 Binding (characterization) of associated with narcan
13) Confidence 0.13 Published 1979 Journal Brain Res. Section Title Doc Link 217494 Disease Relevance 0.09 Pain Relevance 0.22

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