INT156717

Context Info Confidence 0.18 First Reported 2009 Last Reported 2009 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.97 Pain Relevance 0.98

extracellular space (Cxcl1) extracellular region (Cxcl1)

Cxcl1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat chemokine 1 100.00 Hyperalgesia 8 98.90 antagonist 3 97.64 nociceptor 3 90.40 intrathecal 1 86.24 Inflammation 4 79.88 cytokine 1 25.00

Disease Link Frequency Relevance Heat Cancer 1 100.00 Necrosis 1 100.00 Hyperalgesia 8 98.90 INFLAMMATION 3 79.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Co-administration of the selective P2X3,2/3 receptors antagonist A-317491, or the non-selective P2X3 receptor antagonist, TNP-ATP, with carrageenan blocked the mechanical hyperalgesia induced by carrageenan, and significantly reduced the increased concentration of tumor necrosis factor alpha (TNF-alpha) and chemokine-induced chemoattractant-1 (CINC-1) but not of interleukin-1 beta (IL-1 beta) induced by carrageenan.

Neg (not) Positive_regulation (induced) of Neg (not) Positive_regulation (increased) of CINC-1 associated with chemokine, necrosis, hyperalgesia, cancer and antagonist

1) Confidence 0.18 Published 2009 Journal Pain Section Abstract Doc Link 19081189 Disease Relevance 0.97 Pain Relevance 0.98

General Comments

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