INT156720

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.10
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD1D) histone binding (CD1D) plasma membrane (CD1D)
cytoplasm (CD1D)
Anatomy Link Frequency
intermediate region 1
mast cell 1
body 1
CD1D (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 249 99.32 Very High Very High Very High
Pain 2 73.20 Quite High
addiction 9 63.76 Quite High
cytokine 19 60.00 Quite High
Paracetamol 5 50.00 Quite Low
Inflammation 17 35.12 Quite Low
chemokine 3 12.32 Low Low
psoriasis 7 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 47 93.84 High High
Cancer 59 80.72 Quite High
Communicable Diseases 5 79.92 Quite High
Contagious Ecthyma 5 75.68 Quite High
Pain 1 73.20 Quite High
Enzootic Bovine Leukosis 13 50.00 Quite Low
Viral Infection 7 46.64 Quite Low
Breast Cancer 4 42.72 Quite Low
INFLAMMATION 18 35.12 Quite Low
Infection 35 20.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lesions of E-C D consist of lipid-storing CD68 (+) and CD1a (-) non-Langerhans cell histiocytes, either localized to the bone or involving multiple systems of the body as well.
Localization (localized) of CD1a in body
1) Confidence 0.68 Published 2008 Journal Hell J Nucl Med Section Abstract Doc Link 19081860 Disease Relevance 0.38 Pain Relevance 0.07
NAC increased HMC-1 and PBMC histamine secretion at concentrations of NAC from 20 to 50 mg/mL and 2.5 to 100 mg/mL, respectively.
Localization (secretion) of HMC-1
2) Confidence 0.65 Published 2010 Journal Clin Toxicol (Phila) Section Body Doc Link 20136478 Disease Relevance 0 Pain Relevance 0
GalCer revealed the unique requirement of both A' and C' CD1d pocket-binding chain structure of ?
Localization (pocket) of CD1d
3) Confidence 0.33 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 0.64 Pain Relevance 0.03
The R3 and G4 open reading frames (orfs) belong to an intermediate region located between the envelope and the tax/rex genes.
Localization (located) of R3 in intermediate region
4) Confidence 0.13 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.08 Pain Relevance 0
Our experiments showed similar histamine release from the mast cell line HMC-1 stimulated with morphine with or without 0.1% sodium bisulfite.
Localization (release) of HMC-1 in mast cell associated with morphine
5) Confidence 0.05 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526189 Disease Relevance 0 Pain Relevance 0.43
Histamine release from HMC-1 cells incubated with morphine 668?
Localization (release) of HMC-1 associated with morphine
6) Confidence 0.05 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526189 Disease Relevance 0 Pain Relevance 0.96
HMC-1 cells contain histamine and release their histamine content in response to various exogenous stimuli [28-30].
Localization (release) of HMC-1
7) Confidence 0.05 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526189 Disease Relevance 0 Pain Relevance 0.60

General Comments

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