INT156724

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.08
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 2
neuronal 2
CPP (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 98 100.00 Very High Very High Very High
Nicotine 3 97.48 Very High Very High Very High
adenocard 2 94.76 High High
Neurotransmitter 1 90.56 High High
Opioid 1 80.64 Quite High
tetrodotoxin 1 72.60 Quite High
epidural 1 64.32 Quite High
Ultiva 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 5 100.00 Very High Very High Very High
Cv General 3 Under Development 93 95.52 Very High Very High Very High
Brain Injury 8 84.72 Quite High
Hemorrhagic Shock 3 82.72 Quite High
Recurrence 1 75.48 Quite High
Coronary Heart Disease 1 75.00 Quite High
Stroke 2 64.32 Quite High
Cerebral Edema 4 60.60 Quite High
Injury 5 57.28 Quite High
Hematoma 1 44.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then summarize the neuronal substrates that underlie CPP induced by these drugs from a genetic perspective.
Positive_regulation (underlie) of Positive_regulation (induced) of CPP in neuronal
1) Confidence 0.40 Published 2008 Journal ScientificWorldJournal Section Abstract Doc Link 19082419 Disease Relevance 0.08 Pain Relevance 0.26
TTX (2 microM) significantly (p < 0.05) reduced PC-induced increases of CPP and LVEDP.
Positive_regulation (induced) of Positive_regulation (increases) of CPP
2) Confidence 0.14 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19403851 Disease Relevance 0.07 Pain Relevance 0.16
Furthermore, Prough et al. observed a higher regional cerebral blood flow in dogs with induced intracerebral hemorrhage after hypertonic saline without any increase of the CPP [43].
Positive_regulation (induced) of Neg (without) Positive_regulation (increase) of CPP in blood associated with cv general 4 under development and cva
3) Confidence 0.06 Published 2005 Journal Crit Care Section Body Doc Link PMC1297608 Disease Relevance 0.93 Pain Relevance 0.32

General Comments

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