INT156727

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.10
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Arg1) aging (Arg1) cytoplasm (Arg1)
Anatomy Link Frequency
vagina 2
erythrocyte 1
Arg1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 27 99.50 Very High Very High Very High
Inflammation 39 97.58 Very High Very High Very High
anesthesia 7 89.12 High High
Pain 9 43.08 Quite Low
endometriosis 3 20.48 Low Low
Central nervous system 15 5.00 Very Low Very Low Very Low
Thalamus 12 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 2 99.24 Very High Very High Very High
INFLAMMATION 42 97.58 Very High Very High Very High
Infection 87 94.40 High High
Sprains And Strains 6 91.44 High High
Reprotox - General 2 15 90.72 High High
Breast Cancer 33 66.84 Quite High
Endometriosis (extended) 15 65.56 Quite High
Stress 1 53.52 Quite High
Body Weight 27 44.08 Quite Low
Pain 9 43.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, increased ER expression and decreased arginase activity were observed in both tamoxifen-infused and ovariectomized rats in this study.
Gene_expression (expression) of arginase
1) Confidence 0.44 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0 Pain Relevance 0
To further characterize the effects of tamoxifen in the vagina, we determined ER concentration and arginase enzyme activity in vaginal tissue extracts.
Spec (determined) Gene_expression (concentration) of arginase in vagina
2) Confidence 0.44 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0 Pain Relevance 0
We further assessed changes in ER expression and arginase activity as estrogen-dependent markers in the vagina.


Gene_expression (expression) of arginase in vagina
3) Confidence 0.39 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1590006 Disease Relevance 0.48 Pain Relevance 0
Activities of erythrocyte NOS and arginase enzymes and serum total cholesterol levels were also measured.
Gene_expression (Activities) of arginase in erythrocyte associated with disorder of lipid metabolism
4) Confidence 0.07 Published 2008 Journal Nutr Res Section Abstract Doc Link 19083410 Disease Relevance 0.25 Pain Relevance 0.09
Anti-inflammatory interleukins such as IL-4 and IL-10 are inducers of arginase isoforms, although these cytokines are known to act on the expression of arginase I, but not that of arginase II [28].
Gene_expression (expression) of arginase associated with inflammation and cytokine
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821905 Disease Relevance 0.62 Pain Relevance 0.44
Anti-inflammatory interleukins such as IL-4 and IL-10 are inducers of arginase isoforms, although these cytokines are known to act on the expression of arginase I, but not that of arginase II [28].
Gene_expression (expression) of arginase associated with inflammation and cytokine
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821905 Disease Relevance 0.62 Pain Relevance 0.44
In the periphery, the NO production decrease may reflect an arginase-mediated synthesis of polyamines necessary to trypanosome growth.
Gene_expression (synthesis) of arginase
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2821905 Disease Relevance 0.13 Pain Relevance 0

General Comments

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