INT15673

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Context Info
Confidence 0.69
First Reported 1991
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.62
Pain Relevance 3.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
Peripheral nerve 2
ganglia 2
ventral 2
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 49 100.00 Very High Very High Very High
Dorsal horn 3 99.90 Very High Very High Very High
Central grey 2 99.52 Very High Very High Very High
Delta opioid receptors 2 99.52 Very High Very High Very High
Sciatic nerve 3 99.00 Very High Very High Very High
Root ganglion neuron 1 98.68 Very High Very High Very High
Enkephalin 1 91.32 High High
Somatostatin 4 90.92 High High
agonist 4 89.56 High High
opioid receptor 7 89.24 High High
Disease Link Frequency Relevance Heat
Shock 6 99.98 Very High Very High Very High
Urological Neuroanatomy 2 99.52 Very High Very High Very High
Ganglion Cysts 1 98.48 Very High Very High Very High
Ulcers 19 90.00 High High
Increased Venous Pressure Under Development 2 78.24 Quite High
Neuropathic Pain 2 72.36 Quite High
Peptic Ulcer 1 27.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of CCK-A receptor mRNA and cNOS mRNA was significantly increased in rats treated with CCK-8 and camostate, whereas CCK-B receptor mRNA remained unaffected.
Positive_regulation (increased) of Transcription (mRNA) of CCK associated with cholecystokinin
1) Confidence 0.69 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10458643 Disease Relevance 0.89 Pain Relevance 0.78
However, sciatic nerve section was associated with a marked ipsilateral increase in both CCK-B receptor mRNA levels in these ganglia (+70%) and the autoradiographic labeling of CCK-B receptors by [3H]pBC 264 (+160%) in the superficial layers of the lumbar dorsal horn.
Positive_regulation (increase) of Transcription (levels) of CCK in ganglia associated with dorsal horn, sciatic nerve and cholecystokinin
2) Confidence 0.47 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 9930763 Disease Relevance 0.07 Pain Relevance 1.07
Repeated electroconvulsive shock increases tachykinin and cholecystokinin mRNA expression in ventral periaqueductal gray.
Positive_regulation (increases) of Transcription (expression) of cholecystokinin in ventral associated with shock, central grey and cholecystokinin
3) Confidence 0.40 Published 1991 Journal Neuroscience Section Title Doc Link 1754069 Disease Relevance 0.56 Pain Relevance 0.30
Peripheral nerve lesions have previously been shown to down-regulate mu- and delta-opioid receptors in the dorsal horn, to increase the gene-expression of CCK and CCK-receptor mRNA in dorsal root ganglion neurons and to alter the potassium-induced spinal CCK-LI release.
Positive_regulation (increase) of Transcription (expression) of CCK in Peripheral nerve associated with ganglion cysts, root ganglion neuron, dorsal horn, delta opioid receptors and cholecystokinin
4) Confidence 0.19 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11432973 Disease Relevance 0.10 Pain Relevance 1.69

General Comments

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