INT15674

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Context Info
Confidence 0.68
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 4.97
Pain Relevance 6.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
neurons 8
DRG 4
ganglia 3
dorsal 2
CAR 2
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 12 100.00 Very High Very High Very High
Cholecystokinin 7 100.00 Very High Very High Very High
Pain 27 99.92 Very High Very High Very High
Dopamine 14 99.84 Very High Very High Very High
qutenza 6 99.84 Very High Very High Very High
dorsal root ganglion 15 99.82 Very High Very High Very High
Neuropeptide 9 99.80 Very High Very High Very High
Dynorphin 5 99.80 Very High Very High Very High
Central grey 5 99.52 Very High Very High Very High
Causalgia 3 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 6 99.98 Very High Very High Very High
Ganglion Cysts 18 99.82 Very High Very High Very High
Asthma 1 99.58 Very High Very High Very High
Urological Neuroanatomy 5 99.52 Very High Very High Very High
Bronchial Hyperreactivity 1 99.20 Very High Very High Very High
Causalgia 3 99.16 Very High Very High Very High
Colitis 2 97.00 Very High Very High Very High
Diverticulitis 1 96.64 Very High Very High Very High
Abdominal Pain 1 95.36 Very High Very High Very High
Nociception 33 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, the induction of PPT gene expression by many of the large neurons undergoing degenerative changes may represent an important biochemical parameter which is associated with the development and persistence of experimental allodynia.
Positive_regulation (induction) of Gene_expression (expression) of PPT gene in neurons associated with allodynia
1) Confidence 0.68 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.53 Pain Relevance 0.40
Injury-induced changes in PPT mRNA expression by affected DRG neurons included: (1) at early postoperative times, generally increased levels of PPT mRNA associated with small and intermediate-size B cells exhibiting normal morphology, (2) at late postoperative times, markedly decreased levels of PPT mRNA associated with degenerating B cells, and (3) induction of PPT gene expression by large A cells which is highly correlated with degenerative morphological changes.
Positive_regulation (induction) of Gene_expression (expression) of PPT gene in neurons associated with injury
2) Confidence 0.68 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.47 Pain Relevance 0.37
Such elevation of the PPTA mRNA expression in the DRG was observed as early as 3 h after formalin injection.
Positive_regulation (elevation) of Gene_expression (expression) of PPTA mRNA in DRG associated with dorsal root ganglion
3) Confidence 0.67 Published 1988 Journal Brain Res. Section Abstract Doc Link 3179743 Disease Relevance 0.53 Pain Relevance 0.26
These results show that the expression of the PPTA gene is activated by chemogenic noxious stimuli.
Positive_regulation (activated) of Gene_expression (expression) of PPTA gene
4) Confidence 0.67 Published 1988 Journal Brain Res. Section Abstract Doc Link 3179743 Disease Relevance 0.41 Pain Relevance 0.25
We showed previously that lipopolysaccharide (LPS) induces noncholinergic airway hyperreactivity to capsaicin via an upregulation of tachykinin synthesis.
Positive_regulation (upregulation) of Gene_expression (synthesis) of tachykinin associated with asthma and qutenza
5) Confidence 0.52 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14613715 Disease Relevance 0.10 Pain Relevance 0.10
Injury-induced changes in PPT mRNA expression by affected DRG neurons included: (1) at early postoperative times, generally increased levels of PPT mRNA associated with small and intermediate-size B cells exhibiting normal morphology, (2) at late postoperative times, markedly decreased levels of PPT mRNA associated with degenerating B cells, and (3) induction of PPT gene expression by large A cells which is highly correlated with degenerative morphological changes.
Positive_regulation (induction) of Gene_expression (expression) of PPT mRNA in neurons associated with injury
6) Confidence 0.49 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.47 Pain Relevance 0.37
Four hours after a single injection of the serotonin 2A/2C receptor agonist, (+/-)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI; 1 mg/kg), PPT mRNA expression was significantly increased in DA-depleted rats across all dorsal subregions of the rostral and caudal striatum as compared to 6-OHDA-treated animals alone.
Positive_regulation (increased) of Gene_expression (expression) of PPT mRNA in dorsal associated with dopamine, agonist and serotonin
7) Confidence 0.42 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11483243 Disease Relevance 0 Pain Relevance 0.56
Analysis of hybridization signals in the emulsion autoradiography showed that the lumbar-5 DRG neurons expressing PPTA mRNAs were significantly increased in number and signal intensity on the formalin-injected side.
Positive_regulation (increased) of Gene_expression (expressing) of PPTA in DRG associated with dorsal root ganglion
8) Confidence 0.42 Published 1988 Journal Brain Res. Section Abstract Doc Link 3179743 Disease Relevance 0.45 Pain Relevance 0.27
Although these results support previous studies suggesting an overall positive regulatory role of serotonin on striatal tachykinin biosynthesis, PPT and PPE gene regulation in certain striatal subregions may by differentially sensitive to lowered 5-HT neurotransmission.
Positive_regulation (role) of Gene_expression (biosynthesis) of tachykinin associated with serotonin
9) Confidence 0.41 Published 1996 Journal Brain Res. Section Abstract Doc Link 8891265 Disease Relevance 0 Pain Relevance 0.20
The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration.
Positive_regulation (formalin-induced) of Gene_expression (expression) of tachykinin in ganglia associated with pain, opiate and spinal cord
10) Confidence 0.24 Published 1995 Journal Neuroscience Section Title Doc Link 7536308 Disease Relevance 0.33 Pain Relevance 0.89
The study reveals that repeated administration of GBR enhances the levels of tachykinin and dynorphin peptides in striatonigral neurons by a stimulus-transcription-biosynthesis coupling mechanism.
Positive_regulation (enhances) of Gene_expression (levels) of tachykinin in neurons associated with dynorphin
11) Confidence 0.21 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.66
Prolonged elevation of galanin and tachykinin expression in mucosal and myenteric enteric nerves in trinitrobenzene sulphonic acid colitis.
Positive_regulation (elevation) of Gene_expression (expression) of tachykinin in enteric nerves associated with colitis and neuropeptide
12) Confidence 0.13 Published 2008 Journal Neurogastroenterol. Motil. Section Title Doc Link 18208479 Disease Relevance 0.69 Pain Relevance 0.49
Repeated electroconvulsive shock increases tachykinin and cholecystokinin mRNA expression in ventral periaqueductal gray.
Positive_regulation (increases) of Gene_expression (expression) of tachykinin in ventral associated with shock, central grey and cholecystokinin
13) Confidence 0.11 Published 1991 Journal Neuroscience Section Title Doc Link 1754069 Disease Relevance 0.56 Pain Relevance 0.30
-tachykinin) with significantly increased expression in the ipsilateral and contralateral LDH of CAR-P3 rats as compared to those in CONT animals (Table 1).
Positive_regulation (increased) of Gene_expression (expression) of tachykinin in CAR associated with spinal dorsal horn
14) Confidence 0.09 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0 Pain Relevance 0.12
Chronic BTS 74 398 administration did not alter mRNA expression in the 6-OHDA lesioned striatum although small increases in PPT mRNA expression in the intact and sham lesioned striatum were observed.
Positive_regulation (increases) of Gene_expression (expression) of PPT mRNA in striatum
15) Confidence 0.09 Published 2008 Journal J Neural Transm Section Abstract Doc Link 18250952 Disease Relevance 0 Pain Relevance 0.11
The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration.
Positive_regulation (formalin-induced) of in spinal cord Gene_expression (expression) of tachykinin in ganglia associated with pain, opiate and spinal cord
16) Confidence 0.08 Published 1995 Journal Neuroscience Section Title Doc Link 7536308 Disease Relevance 0.33 Pain Relevance 0.89
Our data support that LPS-induced bronchial hyperreactivity to capsaicin is related closely to the upregulation of tachykinin gene expression, but not the upregulation of NEP.
Positive_regulation (upregulation) of Gene_expression (expression) of tachykinin gene associated with bronchial hyperreactivity and qutenza
17) Confidence 0.05 Published 2003 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 12738685 Disease Relevance 0.10 Pain Relevance 0.32

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