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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

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plasma membrane (Esr1, Fshr) endosome (Fshr) enzyme binding (Esr1)
DNA binding (Esr1) protein complex (Esr1) signal transducer activity (Fshr)
Esr1 (Mus musculus)
Fshr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Headache 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the SUMSTAT program, we observed ESR2-ESR1-FSHR significant gene-gene interaction, suggesting association with the MA/MO phenotype (P = .005; P = .003 in females), and with MA alone (P = .021; P = .030 for females).We corroborated that ESR2-ESR1-FSHR haplotypes interacted for migraine under a model-free hypothesis (empirical P = .010 for the whole sample; P = .001 for females), and the association was stronger for the MA phenotype alone (empirical P = 5.0e-4, under the heterogeneity model; P = .001 for females).
ESR1 Positive_regulation (observed) of FSHR Binding (interaction) of
1) Confidence 0.02 Published 2008 Journal Headache Section Body Doc Link 19093296 Disease Relevance 0 Pain Relevance 0

General Comments

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