INT156794

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 41
Total Number 42
Disease Relevance 23.09
Pain Relevance 5.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CISH) intracellular (CISH) molecular_function (CISH)
cellular_component (CISH)
Anatomy Link Frequency
coronary artery 1
capsule 1
CSF 1
brain 1
bladder 1
CISH (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 169 100.00 Very High Very High Very High
bDMF 42 100.00 Very High Very High Very High
Calcium channel 17 100.00 Very High Very High Very High
Opioid 7 99.68 Very High Very High Very High
Neuropeptide 10 99.40 Very High Very High Very High
Ultiva 6 99.10 Very High Very High Very High
Endogenous opioid 4 98.36 Very High Very High Very High
imagery 91 98.20 Very High Very High Very High
Morphine 9 95.64 Very High Very High Very High
Multiple sclerosis 354 94.24 High High
Disease Link Frequency Relevance Heat
Disease 420 100.00 Very High Very High Very High
Carcinoma In Situ 271 100.00 Very High Very High Very High
Syndrome 149 100.00 Very High Very High Very High
Carcinoma 53 100.00 Very High Very High Very High
Asthma 316 99.88 Very High Very High Very High
Cardiovascular Disease 142 99.88 Very High Very High Very High
Staphylococcus Infection 52 99.80 Very High Very High Very High
Cleidocranial Dysplasia 9 99.80 Very High Very High Very High
Seminoma 32 99.64 Very High Very High Very High
Aging 22 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This prospective randomized pilot study compared the influence of fentanyl-based versus remifentanil-based anaesthesia on cytokine responses and expression of the suppressor of cytokine signalling (SOCS)-3 gene following coronary artery bypass graft surgery.
Gene_expression (expression) of SOCS in coronary artery associated with ultiva and cytokine
1) Confidence 0.58 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 19094432 Disease Relevance 0.15 Pain Relevance 0.36
Reduction of signaling by IL-6 cytokines has been associated with treatment-induced receptor protein down regulation [16,25], expression of signal modifying SOCS proteins [26] or desensitization of gp130 [27].
Gene_expression (expression) of SOCS associated with cytokine
2) Confidence 0.58 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.06 Pain Relevance 0.23
Here, we present a fine-scale functional analysis of segregating variation within the cis-regulatory region of prodynorphin, a gene that encodes an endogenous opioid precursor with roles in cognition and disease.
Gene_expression (region) of cis-regulatory associated with cognitive disorder, endogenous opioid and disease
3) Confidence 0.58 Published 2010 Journal Mol. Biol. Evol. Section Abstract Doc Link 19910384 Disease Relevance 0.19 Pain Relevance 0.10
The review used an approach called critical interpretive synthesis (CIS), which combines conventional systematic review techniques with methods for interpretative synthesis of qualitative research.
Gene_expression (synthesis) of CIS
4) Confidence 0.57 Published 2010 Journal J Pain Symptom Manage Section Abstract Doc Link 19783398 Disease Relevance 0.37 Pain Relevance 0.91
The initial response rate was 92% (45/49), and in two additional patients CIS disappeared, whereas papillary tumors did not.
Gene_expression (disappeared) of CIS associated with cancer and carcinoma in situ
5) Confidence 0.51 Published 2009 Journal World J Urol Section Body Doc Link PMC2694311 Disease Relevance 1.08 Pain Relevance 0
The other 17 patients recurred with pure CIS (n = 5), T1 + CIS (n = 1), Ta + CIS (n = 2), pT1 (n = 3), pTa (n = 5) and pTx (n = 1).
Gene_expression (recurred) of CIS associated with carcinoma in situ
6) Confidence 0.51 Published 2009 Journal World J Urol Section Body Doc Link PMC2694311 Disease Relevance 1.18 Pain Relevance 0.08
The other 17 patients recurred with pure CIS (n = 5), T1 + CIS (n = 1), Ta + CIS (n = 2), pT1 (n = 3), pTa (n = 5) and pTx (n = 1).
Gene_expression (recurred) of CIS associated with carcinoma in situ
7) Confidence 0.51 Published 2009 Journal World J Urol Section Body Doc Link PMC2694311 Disease Relevance 1.18 Pain Relevance 0.08
The other 17 patients recurred with pure CIS (n = 5), T1 + CIS (n = 1), Ta + CIS (n = 2), pT1 (n = 3), pTa (n = 5) and pTx (n = 1).
Gene_expression (recurred) of CIS associated with carcinoma in situ
8) Confidence 0.51 Published 2009 Journal World J Urol Section Body Doc Link PMC2694311 Disease Relevance 1.17 Pain Relevance 0.07
Bropirimine, an oral immunomodulator, was studied in BCG-resistant CIS in a phase-II trial [23].
Gene_expression (resistant) of CIS associated with carcinoma in situ
9) Confidence 0.46 Published 2009 Journal World J Urol Section Body Doc Link PMC2694311 Disease Relevance 0.75 Pain Relevance 0
The model produced adjusted odds ratios and 99% CIs.


Gene_expression (produced) of CIs
10) Confidence 0.42 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283363 Disease Relevance 0.23 Pain Relevance 0.16
Table 4 illustrates, for selected groups of patients, ozone exposure effects as a function of patient age, expressed as ORs and CIs for cellulitis (in a broad sense) vs.
Gene_expression (expressed) of CIs associated with staphylococcus infection
11) Confidence 0.34 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2996226 Disease Relevance 0.58 Pain Relevance 0
Cerebrospinal fluid (CSF) is a promising source of biochemical markers in CIS, since the CSF compartment is in close anatomical contact with the brain interstitial fluid, and reflects biochemical changes associated with the disease [42], [43].
Gene_expression (source) of CIS in CSF associated with syndrome and disease
12) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916843 Disease Relevance 1.79 Pain Relevance 0.47
Genes identified as possibly “causal” to obesity can subsequently be interrogated for association with BMI in a large GWA study cohort in order to establish whether the genes harbor sequence variants that effect their expression in cis.
Gene_expression (expression) of cis associated with obesity
13) Confidence 0.28 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2880558 Disease Relevance 0.89 Pain Relevance 0
We have performed PDT on 131 cases (95 CIS, 31 dysplasia, 1 vulval dysplasia (VIN),
Gene_expression (performed) of CIS associated with cleidocranial dysplasia
14) Confidence 0.27 Published 1999 Journal Diagn Ther Endosc Section Abstract Doc Link PMC2362637 Disease Relevance 0.72 Pain Relevance 0.18
CIS Checklist Individual Strength

Competing interests

Gene_expression (interests) of CIS
15) Confidence 0.26 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1851952 Disease Relevance 0.27 Pain Relevance 0.23
A further orally applicable platinum(IV) anticancer drug currently under development is cis, trans, cis-diammine-dihydroxido-dichlorido-platinum(IV) (oxoplatin) which was synthesized by Chugaev and Khlopin for the first time in the Russian Federation in 1927 [26].
Gene_expression (synthesized) of cis
16) Confidence 0.22 Published 2009 Journal Metal-Based Drugs Section Body Doc Link PMC2705772 Disease Relevance 0.31 Pain Relevance 0
Further, CSF and serum CxCL-13 levels of patients with CIS, RRMS and CPMS had similar ranges and also CSF?
Gene_expression (levels) of CIS
17) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.31 Pain Relevance 0.34
A further orally applicable platinum(IV) anticancer drug currently under development is cis, trans, cis-diammine-dihydroxido-dichlorido-platinum(IV) (oxoplatin) which was synthesized by Chugaev and Khlopin for the first time in the Russian Federation in 1927 [26].
Gene_expression (synthesized) of cis
18) Confidence 0.19 Published 2009 Journal Metal-Based Drugs Section Body Doc Link PMC2705772 Disease Relevance 0.31 Pain Relevance 0
A gain of activity of the KIT gene, a member of the tyrosine kinase family, appears to play a role in the progression of CIS towards seminomas [17].
Gene_expression (progression) of CIS associated with seminoma and carcinoma in situ
19) Confidence 0.18 Published 2008 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2735737 Disease Relevance 1.54 Pain Relevance 0
The ORs and 95% CIs associated with pesticide use in and around the home are presented in Table 2.
Gene_expression (presented) of CIs
20) Confidence 0.18 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247516 Disease Relevance 0.27 Pain Relevance 0

General Comments

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