INT156799

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.29
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gria1, Grm8) cytosol (Gria1) endoplasmic reticulum (Gria1)
protein complex (Gria1) signal transducer activity (Grm8)
Anatomy Link Frequency
RVM 2
Gria1 (Rattus norvegicus)
Grm8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 4 100.00 Very High Very High Very High
Glutamate receptor 4 100.00 Very High Very High Very High
Rostral ventromedial medulla 12 98.68 Very High Very High Very High
amygdala 8 97.52 Very High Very High Very High
nMDA receptor antagonist 2 97.20 Very High Very High Very High
Glutamate 2 96.58 Very High Very High Very High
Pain 14 88.68 High High
antagonist 4 85.04 High High
Peripheral nerve injury 2 82.00 Quite High
Antinociceptive 4 72.00 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 2 92.48 High High
Pain 10 88.68 High High
Nervous System Injury 4 82.00 Quite High
Peripheral Neuropathy 6 66.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While glutamate or an NMDA receptor antagonist in the amygdala failed to induce marked changes in discharge rates of RVM cells, amygdaloid administration of DHPG, a group I metabotropic glutamate receptor (mGluR) agonist acting on mGluR(1) and mGluR(5), increased discharge rates of presumably pronociceptive RVM ON-cells in nerve-injured but not sham-operated animals.
glutamate receptor Regulation (acting) of mGluR in RVM associated with nmda receptor antagonist, glutamate, glutamate receptor, agonist, amygdala and rostral ventromedial medulla
1) Confidence 0.11 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19094988 Disease Relevance 0.65 Pain Relevance 1.22
While glutamate or an NMDA receptor antagonist in the amygdala failed to induce marked changes in discharge rates of RVM cells, amygdaloid administration of DHPG, a group I metabotropic glutamate receptor (mGluR) agonist acting on mGluR(1) and mGluR(5), increased discharge rates of presumably pronociceptive RVM ON-cells in nerve-injured but not sham-operated animals.
glutamate receptor Regulation (acting) of mGluR in RVM associated with nmda receptor antagonist, glutamate, glutamate receptor, agonist, amygdala and rostral ventromedial medulla
2) Confidence 0.11 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19094988 Disease Relevance 0.65 Pain Relevance 1.22

General Comments

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