INT156802

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 12
Disease Relevance 9.13
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fetub) extracellular region (Fetub)
Anatomy Link Frequency
cavity 4
embryo 1
white blood cells 1
Fetub (Rattus norvegicus)
Pain Link Frequency Relevance Heat
positron emission tomography 638 100.00 Very High Very High Very High
imagery 297 99.80 Very High Very High Very High
Inflammation 66 91.88 High High
Pain 1 85.92 High High
palliative 11 62.40 Quite High
Disease Link Frequency Relevance Heat
Toxicity 14 99.86 Very High Very High Very High
Cancer 836 99.24 Very High Very High Very High
Disease 44 99.08 Very High Very High Very High
Glioma 143 98.12 Very High Very High Very High
Soft Tissue Infections 22 98.08 Very High Very High Very High
Recurrence 341 96.92 Very High Very High Very High
Necrosis 66 93.04 High High
INFLAMMATION 66 91.88 High High
Anaplastic Astrocytoma 55 88.36 High High
Pain 1 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Is the fish embryo toxicity test (FET) with the zebrafish (Danio rerio) a potential alternative for the fish acute toxicity test?
Positive_regulation (alternative) of FET in embryo associated with toxicity
1) Confidence 0.43 Published 2009 Journal Comp. Biochem. Physiol. C Toxicol. Pharmacol. Section Title Doc Link 19095081 Disease Relevance 0.95 Pain Relevance 0.09
In contrast, focally increased FET uptake is an early and reliable indicator of tumour progression.
Positive_regulation (increased) of FET associated with cancer
2) Confidence 0.42 Published 2006 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC1998889 Disease Relevance 1.18 Pain Relevance 0.47
Only in one patient in whom RIT had been completed as long as 33 months prior to the beginning of FET PET monitoring were the post-therapeutic phase of increasing FET uptake and its peak probably missed.
Positive_regulation (increasing) of FET associated with positron emission tomography
3) Confidence 0.42 Published 2006 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC1998889 Disease Relevance 0.32 Pain Relevance 0.44
Kaim et al. demonstrated that FET uptake was not increased in activated white blood cells of experimental soft tissue infection [33].
Neg (not) Positive_regulation (increased) of FET in white blood cells associated with soft tissue infections
4) Confidence 0.42 Published 2006 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC1998889 Disease Relevance 1.07 Pain Relevance 0.23
The ten patients without obvious tumour at baseline initially presented with normal ratios (TUmax/BG 1.64±0.26) but showed focally increasing FET uptake values, resulting in pathological ratios during follow-up (TUmax/BG 2.67±0.43).
Positive_regulation (increasing) of FET associated with cancer
5) Confidence 0.42 Published 2006 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC1998889 Disease Relevance 0.93 Pain Relevance 0.27
In one of the seven patients with slightly increased stable and homogeneous FET uptake, RIT had been completed about 3 years prior to the beginning of FET PET monitoring; therefore the post-therapeutic phase of increasing FET uptake and its peak were probably missed.
Positive_regulation (increasing) of FET associated with positron emission tomography
6) Confidence 0.42 Published 2006 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC1998889 Disease Relevance 0.37 Pain Relevance 0.15
On FET PET there is slightly increasing homogeneous FET uptake surrounding the cavity (which in this particular case mimics a more focal appearance owing to the small lesion size in combination with the limited resolution of the PET scanner), peaking 15 months after RIT (02/01) and decreasing during further follow-up.
Positive_regulation (increasing) of FET PET in cavity associated with positron emission tomography
7) Confidence 0.42 Published 2006 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC1998889 Disease Relevance 0.74 Pain Relevance 0.30
Homogeneous, slightly increasing FET uptake around the tumour cavity with a peak up to 18 months after RIT, followed by stable or decreasing FET uptake, is indicative of benign, therapy-related changes.
Positive_regulation (increasing) of FET in cavity associated with cancer
8) Confidence 0.31 Published 2006 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC1998889 Disease Relevance 0.99 Pain Relevance 0.47
Even in one patient without focal contrast enhancement on MRI, PET showed focally increased FET uptake clearly indicating tumour regrowth, which was later proven by biopsy.
Positive_regulation (increased) of FET associated with cancer, positron emission tomography and imagery
9) Confidence 0.31 Published 2006 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC1998889 Disease Relevance 0.44 Pain Relevance 0.21
These results strongly encourage the evaluation of FET PET for monitoring of other forms of locoregional glioma therapy.
Positive_regulation (evaluation) of FET PET associated with positron emission tomography and glioma
10) Confidence 0.31 Published 2006 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC1998889 Disease Relevance 1.07 Pain Relevance 0.38
Six of these seven patients demonstrated slightly increasing homogeneous FET uptake surrounding the resection cavity without any signs of additional nodular uptake; this uptake presented with a peak (baseline TUmax/BG 1.78±0.30, peak TUmax/BG 2.07±0.25, mean±SD) up to 18 months after RIT, followed by stable or decreasing values (last follow-up TUmax/BG 1.63±0.22; representative example in Fig. 1).
Positive_regulation (increasing) of FET in cavity
11) Confidence 0.31 Published 2006 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC1998889 Disease Relevance 0.33 Pain Relevance 0.16
On FET PET there is slightly increasing homogeneous FET uptake surrounding the cavity (which in this particular case mimics a more focal appearance owing to the small lesion size in combination with the limited resolution of the PET scanner), peaking 15 months after RIT (02/01) and decreasing during further follow-up.
Positive_regulation (increasing) of FET in cavity associated with positron emission tomography
12) Confidence 0.31 Published 2006 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC1998889 Disease Relevance 0.74 Pain Relevance 0.29

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