INT156805

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.09
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ebp) endoplasmic reticulum (Ebp)
Anatomy Link Frequency
small intestine 1
Ebp (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 8 99.00 Very High Very High Very High
Buprenorphine 4 79.84 Quite High
transdermal 4 79.28 Quite High
Pain 2 75.00 Quite High
aspirin 5 69.60 Quite High
cINOD 4 43.44 Quite Low
Inflammation 21 5.00 Very Low Very Low Very Low
endometriosis 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microsatellite Instability 67 100.00 Very High Very High Very High
Colorectal Cancer 25 99.26 Very High Very High Very High
Cancer 355 99.12 Very High Very High Very High
Polyps 98 91.76 High High
Colon Cancer 109 91.24 High High
Adenocarcinoma 21 90.60 High High
Adenoma 145 89.80 High High
Hyperplasia 46 83.28 Quite High
Malignant Neoplastic Disease 11 75.00 Quite High
Pain 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
So far, it is questionable whether the introduction of LD-TD-BUP actually has stabilised opioids consumption or whether it has complicated and increased the consumption of potentially addictive drugs.
Gene_expression (introduction) of LD-TD-BUP associated with opioid
1) Confidence 0.40 Published 2009 Journal Eur J Pain Section Abstract Doc Link 19095476 Disease Relevance 0.22 Pain Relevance 0.52
We studied all prescriptions of opioids and other potentially addictive drugs to patients receiving at least two LD-TD-BUP prescriptions during 2004-2006.
Gene_expression (prescriptions) of LD-TD-BUP associated with opioid
2) Confidence 0.40 Published 2009 Journal Eur J Pain Section Abstract Doc Link 19095476 Disease Relevance 0.24 Pain Relevance 0.49
CIMP-high colorectal cancers are inversely correlated with COX-2 overexpression independent of MSI status [27].
Gene_expression (overexpression) of MSI associated with colorectal cancer and microsatellite instability
3) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2257954 Disease Relevance 2.46 Pain Relevance 0.06
MSI, including MLH1 hypermethylation, has also been found in a number of human tumors of the small intestine (Ruemmele et al., 2009).
Gene_expression (found) of MSI in small intestine associated with cancer and microsatellite instability
4) Confidence 0.05 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 1.05 Pain Relevance 0
MSI was found in 40 out of 64 (62.5%) HNPCC and suspected-HNPCC cases.
Gene_expression (found) of MSI associated with microsatellite instability
5) Confidence 0.04 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 0.91 Pain Relevance 0
MSI is also found in about 15% of sporadic CRCs and is usually the result of acquired loss of the mismatch repair gene hMLH1 (Thibodeau et al. 1993).
Gene_expression (found) of MSI associated with microsatellite instability
6) Confidence 0.04 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717819 Disease Relevance 1.20 Pain Relevance 0

General Comments

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