INT156818

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 3.93
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Plasma 1
liver 1
Coq10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 5 97.48 Very High Very High Very High
Glutamate 34 97.36 Very High Very High Very High
Pain 5 91.40 High High
Angina 8 90.88 High High
imagery 15 82.40 Quite High
adenocard 4 79.76 Quite High
fibrosis 16 65.96 Quite High
Tetrahydrobiopterin 4 63.52 Quite High
qutenza 4 25.00 Low Low
Inflammation 10 16.28 Low Low
Disease Link Frequency Relevance Heat
Hyperlipoproteinemia Type Ii 5 99.64 Very High Very High Very High
Neurodegenerative Disease 4 99.28 Very High Very High Very High
Parkinson's Disease 1 98.68 Very High Very High Very High
Cv Unclassified Under Development 5 97.48 Very High Very High Very High
Apoptosis 51 94.16 High High
Confusion 4 93.32 High High
Pressure Volume 2 Under Development 4 92.60 High High
Myalgia 4 91.40 High High
Angina 4 90.88 High High
Fatigue 4 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Takayama et al. [28] have observed that coenzyme Q10 lowers the increased level of serum LDH in rats subjected to hepatic ischemia-reperfusion
Gene_expression (lowers) of coenzyme Q10 associated with ischemia
1) Confidence 0.33 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.18 Pain Relevance 0.05
Treatment with a combination of L-carnitine and coenzyme Q10 (prior to CCl4 injection) resulted in a significant increase in isoenzyme 4 and a significant decrease in isoenzyme 1, isoenzyme 2, isoenzyme 3 and isoenzyme 5.
Gene_expression (injection) of coenzyme Q10
2) Confidence 0.33 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.22 Pain Relevance 0.04
Coenzyme Q10 (CoQ10) or ubiquinone is a vitamin-like substance which is found in small amounts in a wide variety of foods and is synthesized in all tissues.
Gene_expression (synthesized) of Coenzyme Q10
3) Confidence 0.29 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.70 Pain Relevance 0.26
Coenzyme Q10 (CoQ10) or ubiquinone is a vitamin-like substance which is found in small amounts in a wide variety of foods and is synthesized in all tissues.
Gene_expression (synthesized) of CoQ10
4) Confidence 0.29 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.70 Pain Relevance 0.25
We purified an NADPH-dependent coenzyme Q reductase (NADPH-CoQ reductase) in rat liver cytosol and compared its enzymatic properties with those of the other CoQ10 reductases such as NADPH: quinone acceptor oxidoreductase 1 (NQO1), lipoamide dehydrogenase, thioredoxine reductase and glutathione reductase.
Gene_expression (reductases) of CoQ10 in liver
5) Confidence 0.26 Published 2008 Journal Biofactors Section Abstract Doc Link 19096101 Disease Relevance 0 Pain Relevance 0
NADPH-CoQ reductase was the only enzyme that preferred NADPH to NADH as an electron donor and was also different from the other CoQ10 reductases in the sensitivities to its inhibitors and stimulators.
Gene_expression (reductases) of CoQ10
6) Confidence 0.26 Published 2008 Journal Biofactors Section Abstract Doc Link 19096101 Disease Relevance 0 Pain Relevance 0
Especially, Zn2+ was the most powerful inhibitor for NADPH-CoQ reductase, but CoQ10 reduction by the other CoQ10 reductases could not be inhibited by Zn2+.
Gene_expression (reductases) of CoQ10
7) Confidence 0.26 Published 2008 Journal Biofactors Section Abstract Doc Link 19096101 Disease Relevance 0 Pain Relevance 0
Especially, Zn2+ was the most powerful inhibitor for NADPH-CoQ reductase, but CoQ10 reduction by the other CoQ10 reductases could not be inhibited by Zn2+.
Gene_expression (reduction) of CoQ10
8) Confidence 0.23 Published 2008 Journal Biofactors Section Abstract Doc Link 19096101 Disease Relevance 0 Pain Relevance 0
CoQ10 has been safely used in patients with neurodegenerative disorders (Levy et al., 2006; Liu, 2007).
Gene_expression (used) of CoQ10 associated with neurodegenerative disease
9) Confidence 0.14 Published 2008 Journal Progress in Brain Research Section Body Doc Link PMC2603274 Disease Relevance 1.11 Pain Relevance 0.14
CoQ10 is an endogenously synthesized compound that acts as an electron carrier in the Complex II of the mitochondrial electron transport chain.
Gene_expression (synthesized) of CoQ10
10) Confidence 0.04 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1131912 Disease Relevance 0.52 Pain Relevance 0.03
Plasma levels of CoQ10 were reduced by atorvastatin (–26.1%, P = 0.0007), but not by pitavastatin (–7.7%, P = 0.39).80

Effects on glucose metabolism

Gene_expression (levels) of CoQ10 in Plasma
11) Confidence 0.02 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.49 Pain Relevance 0

General Comments

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