INT156820

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.49
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Plasma 1
Coq10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 1 25.00 Low Low
Inflammation 15 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperlipoproteinemia Type Ii 15 99.24 Very High Very High Very High
Adverse Drug Reaction 90 98.74 Very High Very High Very High
Diabetes Mellitus 36 68.56 Quite High
Hyperlipidemia 24 66.72 Quite High
Congenital Anomalies 6 64.20 Quite High
Dyslipidemia /

Combined Dyslipidemia

48 50.00 Quite Low
Disorders Of Creatine Metabolism 3 48.12 Quite Low
Disorder Of Lipid Metabolism 120 5.00 Very Low Very Low Very Low
Coronary Artery Disease 54 5.00 Very Low Very Low Very Low
Metabolic Syndrome 51 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Especially, Zn2+ was the most powerful inhibitor for NADPH-CoQ reductase, but CoQ10 reduction by the other CoQ10 reductases could not be inhibited by Zn2+.
Negative_regulation (reduction) of CoQ10
1) Confidence 0.15 Published 2008 Journal Biofactors Section Abstract Doc Link 19096101 Disease Relevance 0 Pain Relevance 0
An open, randomized, cross-over study using pitavastatin 4 mg and atorvastatin 20 mg was conducted to compare their efficacy, safety, and effect to decrease the CoQ10 levels at an increased dose of them in 19 Japanese patients with heterozygous familial hypercholesterolemia.
Negative_regulation (decrease) of CoQ10 associated with hyperlipoproteinemia type ii
2) Confidence 0.01 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.54 Pain Relevance 0
Plasma levels of CoQ10 were reduced by atorvastatin (–26.1%, P = 0.0007), but not by pitavastatin (–7.7%, P = 0.39).80

Effects on glucose metabolism

Neg (not) Negative_regulation (reduced) of CoQ10 in Plasma
3) Confidence 0.01 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.49 Pain Relevance 0
ADRs due to high-dose statins are reported to be associated with a decrease in coenzyme Q10 (CoQ10).
Negative_regulation (decrease) of CoQ10 associated with adverse drug reaction
4) Confidence 0.01 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.45 Pain Relevance 0

General Comments

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