INT156823

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.49
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Plasma 2
liver 2
Coq10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 2 25.00 Low Low
Inflammation 5 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperlipoproteinemia Type Ii 5 99.64 Very High Very High Very High
Adverse Drug Reaction 30 84.80 Quite High
Diabetes Mellitus 12 68.56 Quite High
Hyperlipidemia 8 66.72 Quite High
Congenital Anomalies 2 51.52 Quite High
Dyslipidemia /

Combined Dyslipidemia

16 50.00 Quite Low
Disorders Of Creatine Metabolism 1 35.44 Quite Low
Disorder Of Lipid Metabolism 40 5.00 Very Low Very Low Very Low
Coronary Artery Disease 18 5.00 Very Low Very Low Very Low
Metabolic Syndrome 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We purified an NADPH-dependent coenzyme Q reductase (NADPH-CoQ reductase) in rat liver cytosol and compared its enzymatic properties with those of the other CoQ10 reductases such as NADPH: quinone acceptor oxidoreductase 1 (NQO1), lipoamide dehydrogenase, thioredoxine reductase and glutathione reductase.
Negative_regulation (thioredoxine reductase) of Gene_expression (reductases) of CoQ10 in liver
1) Confidence 0.17 Published 2008 Journal Biofactors Section Abstract Doc Link 19096101 Disease Relevance 0 Pain Relevance 0
Especially, Zn2+ was the most powerful inhibitor for NADPH-CoQ reductase, but CoQ10 reduction by the other CoQ10 reductases could not be inhibited by Zn2+.
Negative_regulation (inhibited) of Gene_expression (reduction) of CoQ10
2) Confidence 0.15 Published 2008 Journal Biofactors Section Abstract Doc Link 19096101 Disease Relevance 0 Pain Relevance 0
Plasma levels of CoQ10 were reduced by atorvastatin (–26.1%, P = 0.0007), but not by pitavastatin (–7.7%, P = 0.39).80

Effects on glucose metabolism

Neg (not) Negative_regulation (reduced) of Gene_expression (levels) of CoQ10 in Plasma
3) Confidence 0.01 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.49 Pain Relevance 0

General Comments

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