INT156831

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.27
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF, MAPK1) nucleoplasm (MAPK1) mitochondrion (MAPK1)
Golgi apparatus (MAPK1) DNA binding (MAPK1) protein complex (MAPK1)
Anatomy Link Frequency
Caco-2 1
EGF (Homo sapiens)
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 1 96.72 Very High Very High Very High
cytokine 118 83.92 Quite High
agonist 2 72.36 Quite High
Inflammation 26 50.00 Quite Low
Inflammatory mediators 16 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 32 96.50 Very High Very High Very High
Lung Cancer 32 82.24 Quite High
INFLAMMATION 42 50.00 Quite Low
Chromosome Aberrations 2 23.32 Low Low
Small Cell Lung Carcinoma 2 18.28 Low Low
Malignant Neoplastic Disease 8 16.84 Low Low
Metaplasia 16 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 8 5.00 Very Low Very Low Very Low
Leukemia 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EGF activated ERK to 90 ± 29% of OSM level (Fig. 4A &4B).
EGF Positive_regulation (activated) of ERK
1) Confidence 0.45 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0 Pain Relevance 0.06
In carcinoma cell lines, the major trends included a strong STAT3 activation by LIF (ADLC, H125), an increased (ADLC, H23) or decreased STAT3 activation by IL-6 (H125, H324), a decreased ERK activation by EGF (H522), and a treatment-independent, constitutive activation of the ERK pathway (H23).
EGF Positive_regulation (activation) of ERK associated with carcinoma
2) Confidence 0.30 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.27 Pain Relevance 0.17
We examined the role of the extracellular signal regulated kinases (ERK) in 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3))-induced gene expression in the differentiated Caco-2 cells. 1,25(OH)(2)D(3)-regulated expression of the 25-hydroxyvitamin D, 24-hydroxylase (CYP24) gene (both natural gene and promoter construct) was strongly modulated by altering ERK activity (i.e., reduced by MEK inhibitors and dominant negative (dn) ERK1 and ERK2, activated by epidermal growth factor) but ERK inhibition had no effect on 1,25(OH)(2)D(3)-regulated expression of the transient receptor potential cation channel, subfamily V, member 6 (TRPV6).
epidermal growth factor Positive_regulation (activated) of ERK2 in Caco-2 associated with member 8
3) Confidence 0.13 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19097033 Disease Relevance 0 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox