INT15684

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 65
Total Number 67
Disease Relevance 43.51
Pain Relevance 13.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
plasma 17
coronary artery 3
sympathetic 3
plaques 2
cartilage 1
Serpine1 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 5 99.96 Very High Very High Very High
Nucleus accumbens 6 99.68 Very High Very High Very High
Morphine 12 99.48 Very High Very High Very High
Paracetamol 16 99.40 Very High Very High Very High
Angina 71 99.28 Very High Very High Very High
Inflammation 271 99.12 Very High Very High Very High
Sciatic nerve 3 99.12 Very High Very High Very High
agonist 77 98.78 Very High Very High Very High
Restless leg syndrome 5 98.64 Very High Very High Very High
Central nervous system 33 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 121 100.00 Very High Very High Very High
Adhesions 51 100.00 Very High Very High Very High
Cardiovascular Disease 38 99.98 Very High Very High Very High
Myocardial Infarction 52 99.84 Very High Very High Very High
Coronary Artery Disease 72 99.74 Very High Very High Very High
Ureteral Obstruction 32 99.68 Very High Very High Very High
Cancer 332 99.52 Very High Very High Very High
Injury 37 99.44 Very High Very High Very High
Hyperinsulinism 37 99.34 Very High Very High Very High
Angina 28 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enhancement of PAI-1 mRNA in cardiovascular cells after kainate injection is mediated through the sympathetic nervous system.
Positive_regulation (Enhancement) of PAI-1 in sympathetic nervous system
1) Confidence 0.70 Published 2005 Journal J. Mol. Cell. Cardiol. Section Title Doc Link 15850565 Disease Relevance 0.09 Pain Relevance 0.23
In addition, the adrenergic agonists phenylephrine and adrenaline themselves, but not clonidine, induced PAI-1 with a spatial distribution similar to that of kainate (i.e. in coronary arteries throughout the heart, and in cardiocytes in the left ventricular and atrial myocardium).
Neg (not) Positive_regulation (induced) of PAI-1 in heart associated with agonist and clonidine
2) Confidence 0.70 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15850565 Disease Relevance 0.23 Pain Relevance 0.30
Here we investigated whether the induction of PAI-1 mRNA by kainate could be mediated through sympathetic versus parasympathetic efferent neurons.
Positive_regulation (induction) of PAI-1 in sympathetic
3) Confidence 0.70 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15850565 Disease Relevance 0.09 Pain Relevance 0.26
A single morphine treatment resulted in an increase in protein levels of PAI-1 in the NAc.
Positive_regulation (increase) of PAI-1 in NAc associated with nucleus accumbens and morphine
4) Confidence 0.66 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15948318 Disease Relevance 0.23 Pain Relevance 1.41
The patients displayed significantly increased PAI activity both under the basal conditions (p less than 0.01) and at peak exercise (p less than 0.01) as compared with the controls.
Positive_regulation (increased) of PAI
5) Confidence 0.62 Published 1991 Journal Thromb. Res. Section Abstract Doc Link 1755002 Disease Relevance 0.49 Pain Relevance 0.16
CONCLUSIONS: Patients with LV may have elevated plasma PAI-1 levels.
Positive_regulation (elevated) of PAI-1 in plasma
6) Confidence 0.60 Published 2006 Journal Arch Dermatol Section Body Doc Link 17116837 Disease Relevance 0.06 Pain Relevance 0
This variant is associated with elevated PAI-1 protein levels, impaired fibrinolysis, and increased risk of thrombosis.
Positive_regulation (elevated) of PAI-1 associated with thrombosis
7) Confidence 0.60 Published 2006 Journal Arch Dermatol Section Abstract Doc Link 17116837 Disease Relevance 0.59 Pain Relevance 0.07
Acetaminophen treatment also significantly increased plasminogen activator inhibitor-1 (PAI-1) activity and plasma fibrinogen level, and decreased antithrombin III (AT-III) and protein C activities (P < 0.05).
Positive_regulation (increased) of plasminogen activator inhibitor-1 in plasma associated with paracetamol
8) Confidence 0.53 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.21 Pain Relevance 0.69
Acetaminophen treatment also significantly increased plasminogen activator inhibitor-1 (PAI-1) activity and plasma fibrinogen level, and decreased antithrombin III (AT-III) and protein C activities (P < 0.05).
Positive_regulation (increased) of PAI-1 in plasma associated with paracetamol
9) Confidence 0.53 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.21 Pain Relevance 0.69
We have found that the elevation of PAI-1 mRNA levels, as detected 3 h after systemic administration of kainate, was reduced by mecamylamine, guanethidine and phentolamine, but not by propranolol or atropine.
Positive_regulation (elevation) of PAI-1 associated with guanethidine
10) Confidence 0.50 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15850565 Disease Relevance 0.07 Pain Relevance 0.29
In order to explore PAI-1 impact on the lymphatic vessel recruitment in inflammatory conditions, we applied a model of lymphatic endothelial cell hyperplasia called lymphangioma [24] to PAI-1 WT (n?
Positive_regulation (explore) of PAI-1 in endothelial cell associated with inflammation, lymphangioma and hyperplasia
11) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 1.06 Pain Relevance 0.10
Our in vitro studies which mimic ischemic conditions show increased tPA and PAI-1 expression in OGD astrocytes, and that MSC-astrocyte co-culture concomitantly decreased the PAI-1 expression and increased tPA activity in astrocytes.
Positive_regulation (increased) of PAI in astrocytes
12) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.88 Pain Relevance 0.08
, as well as other chemicals/agents, induce PAI-1 expression in cultured cells and in vivo [68].
Positive_regulation (induce) of PAI
13) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.71 Pain Relevance 0.14
Hence, the results suggest that PAI-1 is likely to be increased during enhanced sympathetic efferent neuronal activity, such as occurring in heart failure or cardiac hypertrophy.
Spec (likely) Positive_regulation (increased) of PAI-1 in sympathetic associated with coronary heart disease and myocardial infarction
14) Confidence 0.47 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15850565 Disease Relevance 0.28 Pain Relevance 0.32
and plasminogen activator inhibitor-1 (PAI-1) are increased in the UUO model (9, 10) and with decreased fibrosis, their expression decreases.
Positive_regulation (increased) of plasminogen activator inhibitor-1 associated with fibrosis and ureteral obstruction
15) Confidence 0.47 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2799997 Disease Relevance 1.44 Pain Relevance 0.37
and plasminogen activator inhibitor-1 (PAI-1) are increased in the UUO model (9, 10) and with decreased fibrosis, their expression decreases.
Positive_regulation (increased) of PAI-1 associated with fibrosis and ureteral obstruction
16) Confidence 0.47 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2799997 Disease Relevance 1.38 Pain Relevance 0.37
We provide for the first time evidence that PAI-1 is dispensable for tumoral lymphangiogenesis associated with breast cancers either induced by mammary carcinoma cell injection or spontaneously appearing in transgenic mice expressing the polyomavirus middle T antigen (PymT) under the control of a mouse mammary tumor virus long-terminal repeat promoter (MMTV-LTR).
Positive_regulation (dispensable) of PAI-1 associated with targeted disruption, cancer, breast cancer and carcinoma
17) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2836381 Disease Relevance 0.82 Pain Relevance 0.07
Although PAI-1 is dispensable for lymphangiogenesis, it is worth noting that other proteolytic systems are mandatory for this process and particularly matrix metalloproteases such as the MMP-2 whose deficiency impairs lymphangiogenesis in in vitro and in vivo models [29].



Positive_regulation (dispensable) of PAI-1
18) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.24 Pain Relevance 0.09
Increasing PAI-1 inhibits tPA activity and subsequently inhibits the tissue damage within the ischemic area [84], [85].
Positive_regulation (Increasing) of PAI
19) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.46 Pain Relevance 0
In sepsis, both the coagulation and the fibrinolytic system may be affected, as indicated by decreased activation of thrombomodulin and protein C as well as reduction of anti-fibrinolysis and enhancement of plasminogen activator inhibitor (PAI)-1 expression [2].
Positive_regulation (enhancement) of PAI associated with sepsis
20) Confidence 0.42 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 1.14 Pain Relevance 0.07

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