INT156850

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 40
Total Number 53
Disease Relevance 24.86
Pain Relevance 4.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (VDR) signal transduction (VDR) cell morphogenesis (VDR)
nucleus (VDR) DNA binding (VDR)
Anatomy Link Frequency
muscle 3
body 2
blood 1
plasma 1
HL-60 1
VDR (Homo sapiens)
VDR - K382E (1)
Pain Link Frequency Relevance Heat
Calcium channel 9 100.00 Very High Very High Very High
Lasting pain 62 99.80 Very High Very High Very High
Arthritis 84 99.52 Very High Very High Very High
depression 51 99.20 Very High Very High Very High
Pain 186 98.56 Very High Very High Very High
Osteoarthritis 52 97.12 Very High Very High Very High
backache 9 94.96 High High
ischemia 9 94.60 High High
aspirin 30 93.92 High High
Chronic low back pain 2 91.00 High High
Disease Link Frequency Relevance Heat
Cognitive Disorder 204 100.00 Very High Very High Very High
Rickets 121 99.92 Very High Very High Very High
Rheumatoid Arthritis 337 99.84 Very High Very High Very High
Depression 61 99.82 Very High Very High Very High
Pain 221 99.80 Very High Very High Very High
Disease 401 99.76 Very High Very High Very High
Mycobacterial Infection 142 99.44 Very High Very High Very High
Pressure Volume 2 Under Development 20 99.24 Very High Very High Very High
Prostate Cancer 726 99.20 Very High Very High Very High
Myalgia 35 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then had 461 to 471 patients and matched control participants to evaluate the potential interactions between plasma vitamin D metabolites and the VDR polymorphisms in relation to prostate cancer risk.
VDR Binding (interactions) of in plasma associated with prostate cancer
1) Confidence 0.47 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1831738 Disease Relevance 0.33 Pain Relevance 0
Our large sample size, especially for patients with clinical aggressive prostate cancer, allowed us to assess the associations of 25(OH)D and 1,25(OH)2D, individually and jointly, with total and aggressive disease, as well as their potential interactions with the VDR polymorphisms.
VDR Binding (interactions) of associated with prostate cancer and disease
2) Confidence 0.47 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1831738 Disease Relevance 0.54 Pain Relevance 0
MEK inhibition reduced 1,25(OH)(2)D(3)-induced 3X-VDRE promoter activity but had no impact on the association of vitamin D receptor (VDR) with chromatin suggesting a role for co-activator recruitment in ERK-modulation of vitamin D-regulated CYP24 gene activation.
VDR Neg (no) Binding (association) of
3) Confidence 0.41 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19097033 Disease Relevance 0 Pain Relevance 0.08
MEK inhibition reduced 1,25(OH)(2)D(3)-induced 3X-VDRE promoter activity but had no impact on the association of vitamin D receptor (VDR) with chromatin suggesting a role for co-activator recruitment in ERK-modulation of vitamin D-regulated CYP24 gene activation.
vitamin D receptor Neg (no) Binding (association) of
4) Confidence 0.41 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19097033 Disease Relevance 0 Pain Relevance 0.08
Conversely, binding of the receptor heterodimer VDR/RXR to the DRE was also observed, although with a lower affinity than to the VDRE (Figure 1A, lanes 2 versus lane 5).
VDR Binding (binding) of
5) Confidence 0.40 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.06 Pain Relevance 0
Since RXR/VDR heterodimers bind the DRE as shown in Figure 1, we next examined the possibility that vitamin D could influence the activity of constructs containing this element.
VDR Spec (examined) Binding (bind) of
6) Confidence 0.40 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.06 Pain Relevance 0
The genetic association is substantial: subjects with the VDR allelic variant TT have a 50?
VDR Binding (subjects) of
7) Confidence 0.36 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128904 Disease Relevance 0.83 Pain Relevance 0.19
Furthermore, we explored the interactions between these vitamin D metabolites and VDR polymorphisms in modifying prostate cancer risk.
VDR Binding (interactions) of associated with prostate cancer
8) Confidence 0.36 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1831738 Disease Relevance 0.77 Pain Relevance 0
Circulating 25-hydroxyvitamin D3 (25[OH]D), the most commonly used index of vitamin D status, is converted to the active hormone 1,25 dihydroxyvitamin D3 (1,25[OH]2D), which, operating through the vitamin D receptor (VDR), inhibits in vitro cell proliferation, induces differentiation and apoptosis, and may protect against prostate cancer.
VDR Binding (operating) of associated with prostate cancer and apoptosis
9) Confidence 0.36 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1831738 Disease Relevance 0.47 Pain Relevance 0
Circulating 25-hydroxyvitamin D3 (25[OH]D), the most commonly used index of vitamin D status, is converted to the active hormone 1,25 dihydroxyvitamin D3 (1,25[OH]2D), which, operating through the vitamin D receptor (VDR), inhibits in vitro cell proliferation, induces differentiation and apoptosis, and may protect against prostate cancer.
vitamin D receptor Binding (operating) of associated with prostate cancer and apoptosis
10) Confidence 0.36 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1831738 Disease Relevance 0.47 Pain Relevance 0
Therefore, it is important to recognize “Subclinical Vitamin D deficiency”.

4.3.

Vitamin D Binding (recognize) of
11) Confidence 0.34 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 0.67 Pain Relevance 0.03
Given that the PHS was a randomized trial, we also tested whether the associations of vitamin D, VDR polymorphisms with prostate cancer were modified by the ?
VDR Binding (associations) of associated with prostate cancer
12) Confidence 0.31 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1831738 Disease Relevance 0.49 Pain Relevance 0.05
Despite intriguing results from laboratory studies, previous epidemiological studies showed inconsistent associations of circulating levels of 25(OH)D, 1,25(OH)2D, and several VDR polymorphisms with prostate cancer risk.
VDR Binding (associations) of associated with prostate cancer
13) Confidence 0.31 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1831738 Disease Relevance 0.80 Pain Relevance 0
As immigrants and members of ethnic minorities are more severely affected by 25-OH vitamin D deficiency, and where any association between vitamin D and chronic pain should be stronger, it is important to re-examine the issue in this particular population subgroup.

2.

vitamin D Spec (examine) Binding (association) of associated with lasting pain
14) Confidence 0.31 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778183 Disease Relevance 0.80 Pain Relevance 0.42
To further clarify the importance of vitamin D to muscle, this study examined the association of vitamin D status and exercise-induced muscle pain and weakness in healthy people.
vitamin D Spec (examined) Binding (association) of in muscle associated with pain and myalgia
15) Confidence 0.31 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3010688 Disease Relevance 0.69 Pain Relevance 0.60
To further clarify the importance of vitamin D to muscle, the present study examined the association of vitamin D status and exercise-induced muscle pain and weakness in healthy people.
vitamin D Spec (examined) Binding (association) of in muscle associated with pain and myalgia
16) Confidence 0.31 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3010688 Disease Relevance 0.90 Pain Relevance 0.65
How does one explain the absence of clinical osteomalacia in individuals with very low vitamin D levels?
vitamin D Binding (individuals) of associated with rickets
17) Confidence 0.31 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2778352 Disease Relevance 1.37 Pain Relevance 0.43
This appears to be the case, because reduced recruitment of p160 coactivators by the RXR/VDR heterodimer bound to the DRE was found.
VDR Binding (bound) of
18) Confidence 0.31 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
Figure 1E compares binding of VDR and RXR with the DR3 and the DRE.
VDR Binding (binding) of
19) Confidence 0.31 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.06 Pain Relevance 0
This inferred association is validated through PubMed search, as 1 alpha,25-dihydroxyvitamin D3, which binds to the Vitamin D receptor, down-regulates the expression of prostate-specific antigen in prostate cancer cells (42).
Vitamin D receptor Binding (binds) of associated with reprotox - general 1
20) Confidence 0.30 Published 2010 Journal J Biomed Discov Collab Section Body Doc Link PMC2990276 Disease Relevance 0.15 Pain Relevance 0

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