INT156853

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.75
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MAPK7) cytosol (MAPK7) nucleoplasm (MAPK7)
signal transduction (MAPK7) nucleus (MAPK7) cell cycle (MAPK7)
Anatomy Link Frequency
Caco-2 1
MAPK7 (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 1 91.36 High High
aspirin 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 1 97.16 Very High Very High Very High
Coronary Artery Disease 66 91.84 High High
Apoptosis 5 61.52 Quite High
Rheumatoid Arthritis 19 5.00 Very Low Very Low Very Low
Atherosclerosis 13 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Myocardial Infarction 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A downstream target of all of the upregulated MAP kinases (ERK5 (MAPK7), p38?
Negative_regulation (kinases) of ERK5
1) Confidence 0.32 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.75 Pain Relevance 0
ERK5-mediated phosphorylation of the transcription factor Ets-1 enhanced 1,25(OH)(2)D(3)-mediated CYP24 gene transcription in proliferating but not differentiated Caco-2 cells due to reduced levels of ERK5 and Ets-1 (total and phosphoprotein levels) in differentiated cells.
Negative_regulation (reduced) of ERK5 in Caco-2
2) Confidence 0.28 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19097033 Disease Relevance 0 Pain Relevance 0.09

General Comments

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