INT156874

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 32.80
Pain Relevance 8.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100a8) extracellular region (S100a8) plasma membrane (S100a8)
cytoskeleton (S100a8) cytoplasm (S100a8)
Anatomy Link Frequency
macrophages 12
bladder 5
CII 4
granulocytes 2
synovium 2
S100a8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 731 100.00 Very High Very High Very High
cytokine 317 100.00 Very High Very High Very High
Inflammatory mediators 42 100.00 Very High Very High Very High
Arthritis 241 99.98 Very High Very High Very High
peripheral neuropathy 2 99.98 Very High Very High Very High
rheumatoid arthritis 132 99.20 Very High Very High Very High
dexamethasone 22 98.20 Very High Very High Very High
metalloproteinase 77 97.88 Very High Very High Very High
Multiple sclerosis 21 96.36 Very High Very High Very High
chemokine 58 94.56 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 808 100.00 Very High Very High Very High
Arthritis 307 99.98 Very High Very High Very High
Peripheral Neuropathy 2 99.98 Very High Very High Very High
Urinary Tract Infection 168 99.96 Very High Very High Very High
Cancer 35 99.96 Very High Very High Very High
Apoptosis 89 99.80 Very High Very High Very High
Necrosis 32 99.72 Very High Very High Very High
Lung Injury 29 99.34 Very High Very High Very High
Rheumatoid Arthritis 132 99.20 Very High Very High Very High
Obesity 450 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We anticipate that the S100A8/A9 expression we found originated from infiltrating granulocytes at infected areas.
Positive_regulation (originated) of Gene_expression (expression) of S100A8 in granulocytes
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 0.91 Pain Relevance 0.10
These data are in line with our results demonstrating that during UTI, levels of S100A8/A9 increased in both bladder and kidney homogenates.
Positive_regulation (increased) of Gene_expression (levels) of S100A8 in bladder associated with urinary tract infection
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.05 Pain Relevance 0.11
Reyes et al. showed that Ureaplasma parvum-induced UTI lead to increased S100A8/A9 expression in bladder tissue however, its contribution was not further investigated [17].
Positive_regulation (increased) of Gene_expression (expression) of S100A8 in bladder associated with urinary tract infection
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.30 Pain Relevance 0.12
In the same year necrotic cells were found to induce pro-inflammatory and tissue repair gene synthesis and cause DC maturation in a TLR2 dependent manner, as a result of the release of their intracellular contents [13, 14].
Positive_regulation (induce) of Gene_expression (synthesis) of pro-inflammatory associated with inflammation
4) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.67 Pain Relevance 0.21
These data are in line with our results demonstrating that during UTI, levels of S100A8/A9 increased in both bladder and kidney homogenates.
Positive_regulation (increased) of in kidney Gene_expression (levels) of S100A8 in bladder associated with urinary tract infection
5) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.05 Pain Relevance 0.11
These preliminary data show that peripheral neuropathy induced over-expression of pro-inflammatory/pro-apoptotic caspases in the orbito-frontal cortex and that ozone, by mechanisms that are as yet unknown, can regulate the expression of the genes that play a pivotal role in the onset and maintenance of allodynia.
Positive_regulation (induced) of Gene_expression (expression) of pro-inflammatory in frontal cortex associated with allodynia, inflammation, urological neuroanatomy, peripheral neuropathy and apoptosis
6) Confidence 0.16 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19100257 Disease Relevance 2.02 Pain Relevance 0.80
The production of pro-inflammatory cytokines was increased in macrophages from ALDP-deficient mice.
Positive_regulation (increased) of Gene_expression (production) of pro-inflammatory in macrophages associated with inflammation and cytokine
7) Confidence 0.08 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613382 Disease Relevance 0.82 Pain Relevance 0.27
In the present study, we firstly demonstrated not only enhanced production of a variety of pro-inflammatory cytokines, but also the accumulation of VLCSFA in detail, utilizing macrophages from ALDP-deficient mice.
Positive_regulation (enhanced) of Gene_expression (production) of pro-inflammatory in macrophages associated with inflammation and cytokine
8) Confidence 0.06 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613382 Disease Relevance 0.75 Pain Relevance 0.25
One of the most prominent modes of mediation of indomethacin-induced gastropathy is the increased expression of the pro-inflammatory cytokines [32, 36], as well as reducing the anti-inflammatory cytokines (IL-10) at the mucosal level.
Positive_regulation (increased) of Gene_expression (expression) of pro-inflammatory associated with inflammation and cytokine
9) Confidence 0.05 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2976071 Disease Relevance 0.51 Pain Relevance 0.54
Furthermore, expression of pro-inflammatory cytokines TNF-?
Positive_regulation (cytokines) of Gene_expression (expression) of pro-inflammatory associated with inflammation and cytokine
10) Confidence 0.03 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.79 Pain Relevance 0.26
5 M CpdA for 5 hrs diminished production of both pro-inflammatory mediators by around 60% based on intracellular flow cytometric analysis (Fig. 1A).
Positive_regulation (mediators) of Gene_expression (production) of pro-inflammatory associated with inflammatory mediators
11) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.78 Pain Relevance 0.40
Enlarged adipocytes, together with the infiltrated macrophages, act in a synergistic manner to cause aberrant production of pro-inflammatory molecules including inducible nitric oxide, cytokines such as tumor necrosis factor-alpha (TNF-?)
Positive_regulation (aberrant) of Gene_expression (production) of pro-inflammatory in macrophages associated with necrosis, inflammation, cancer, obesity and cytokine
12) Confidence 0.03 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 1.79 Pain Relevance 0.29
In this study, Radix Astragali was fractionated and its constituents were repeatedly screened for their activities in inhibiting pro-inflammatory cytokine production and lipopolysaccharide (LPS)-induced activation of the NF-?
Positive_regulation (activation) of Gene_expression (production) of pro-inflammatory associated with inflammation and cytokine
13) Confidence 0.03 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 1.07 Pain Relevance 0.23
Enlarged adipocytes, together with the infiltrated macrophages, act in a synergistic manner to cause aberrant production of pro-inflammatory molecules including inducible nitric oxide, cytokines such as tumor necrosis factor-alpha (TNF-?)
Positive_regulation (as) of Gene_expression (production) of pro-inflammatory in macrophages associated with necrosis, inflammation, cancer, obesity and cytokine
14) Confidence 0.03 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 1.80 Pain Relevance 0.30
Enlarged adipocytes, together with the infiltrated macrophages, act in a synergistic manner to cause aberrant production of pro-inflammatory molecules including inducible nitric oxide, cytokines such as tumor necrosis factor-alpha (TNF-?)
Positive_regulation (cause) of Gene_expression (production) of pro-inflammatory in macrophages associated with necrosis, inflammation, cancer, obesity and cytokine
15) Confidence 0.03 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 1.79 Pain Relevance 0.29
In this study, Radix Astragali was fractionated and its constituents were repeatedly screened for their activities in inhibiting pro-inflammatory cytokine production and lipopolysaccharide (LPS)-induced activation of the NF-?
Positive_regulation (activities) of Gene_expression (production) of pro-inflammatory associated with inflammation and cytokine
16) Confidence 0.03 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 1.11 Pain Relevance 0.26
Enlarged adipocytes, together with the infiltrated macrophages, act in a synergistic manner to cause aberrant production of pro-inflammatory molecules including inducible nitric oxide, cytokines such as tumor necrosis factor-alpha (TNF-?)
Positive_regulation (inducible) of Gene_expression (production) of pro-inflammatory in macrophages associated with necrosis, inflammation, cancer, obesity and cytokine
17) Confidence 0.03 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2936435 Disease Relevance 1.79 Pain Relevance 0.29
Obesity in humans and rodents is associated with increased expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF) ?
Positive_regulation (increased) of Gene_expression (expression) of pro-inflammatory associated with necrosis, inflammation, cancer, obesity and cytokine
18) Confidence 0.03 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.05 Pain Relevance 0.23
Therefore, controlling MMP activity as well as the production of pro-inflammatory cytokines is required for the effective treatment of arthritis.
Positive_regulation (required) of Gene_expression (production) of pro-inflammatory associated with inflammation, arthritis and cytokine
19) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2841253 Disease Relevance 1.43 Pain Relevance 0.91
Hormonal status does not affect arthritis-induced increased levels of pro-inflammatory cytokines, IgG and CII antibodies
Positive_regulation (induced) of Gene_expression (cytokines) of pro-inflammatory in CII associated with inflammation, cytokine and arthritis
20) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 1.33 Pain Relevance 0.45

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