INT156883

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Context Info
Confidence 0.66
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 4.27
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PDF) translation (PDF)
PDF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 87.00 High High
cINOD 10 84.84 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 30 99.84 Very High Very High Very High
Reprotox - General 1 5 89.00 High High
Cancer 10 82.92 Quite High
Stress 15 75.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of dominant negative p53 in LNCaP cells blocked induction of PDF mRNA and protein demonstrating the requirement for functional p53 in PDF induction by these stimuli.
Positive_regulation (induction) of PDF
1) Confidence 0.66 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19100681 Disease Relevance 0.88 Pain Relevance 0.24
Expression of dominant negative p53 in LNCaP cells blocked induction of PDF mRNA and protein demonstrating the requirement for functional p53 in PDF induction by these stimuli.
Positive_regulation (induction) of PDF
2) Confidence 0.66 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19100681 Disease Relevance 0.88 Pain Relevance 0.24
Increased PDF mRNA stability in response to hypoxia and cobalt chloride, but not doxorubicin, indicates that p53-dependent induction of PDF expression occurs via diverse mechanisms.
Positive_regulation (Increased) of PDF associated with hypoxia
3) Confidence 0.57 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19100681 Disease Relevance 0.83 Pain Relevance 0.22
We also show the requirement for de novo protein synthesis in PDF induction by hypoxia and DNA damage.
Positive_regulation (induction) of PDF associated with hypoxia
4) Confidence 0.57 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19100681 Disease Relevance 0.84 Pain Relevance 0.22
Increased PDF mRNA stability in response to hypoxia and cobalt chloride, but not doxorubicin, indicates that p53-dependent induction of PDF expression occurs via diverse mechanisms.
Positive_regulation (stability) of PDF associated with hypoxia
5) Confidence 0.39 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19100681 Disease Relevance 0.83 Pain Relevance 0.22

General Comments

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