INT156896

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Context Info
Confidence 0.76
First Reported 2008
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 7.62
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

growth (Foxp3) nucleus (Foxp3) intracellular (Foxp3)
embryo development (Foxp3) molecular_function (Foxp3) cellular_component (Foxp3)
Anatomy Link Frequency
T cells 4
Treg 2
lymph nodes 1
Tr1 cells 1
monocyte 1
Foxp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 70 99.90 Very High Very High Very High
Neuritis 23 98.34 Very High Very High Very High
tolerance 22 98.32 Very High Very High Very High
Inflammation 94 95.08 Very High Very High Very High
corticosteroid 1 93.76 High High
Sciatic nerve 6 87.80 High High
Peripheral nervous system 2 84.48 Quite High
Inflammatory marker 1 84.24 Quite High
Neuropathic pain 1 82.32 Quite High
abdominal pain 1 81.56 Quite High
Disease Link Frequency Relevance Heat
Chronic Fatigue Syndrome 195 98.44 Very High Very High Very High
Experimental Autoimmune Neuritis 23 98.34 Very High Very High Very High
Gastrointestinal Disease 2 98.00 Very High Very High Very High
Fatigue 66 97.28 Very High Very High Very High
Autoimmune Disease 15 96.12 Very High Very High Very High
Disorder Of Lipid Metabolism 5 95.60 Very High Very High Very High
INFLAMMATION 105 95.08 Very High Very High Very High
Ulcers 2 93.60 High High
Disease 30 90.80 High High
Inflammatory Bowel Disease 2 90.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In lymph nodes of EAN rats, Compound A depressed Th1 and Th17 cytokines, but increased Th2 cytokine and Foxp3 expression.
Gene_expression (expression) of Foxp3 in lymph nodes associated with neuritis and cytokine
1) Confidence 0.76 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19675162 Disease Relevance 1.85 Pain Relevance 1.51
T-regulatory cells expressing the forkhead box transcription factor 3 (Foxp3) play essential roles in immune homeostasis.
Gene_expression (expressing) of Foxp3
2) Confidence 0.60 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19100737 Disease Relevance 0.88 Pain Relevance 0.63
The CD4+ CD25+ regulatory population of T cells (Treg cells), which expresses the forkhead family transcription factor (Foxp3), is the key component of the peripheral tolerance mechanism that protects against a variety of autoimmune diseases [45].
Gene_expression (expresses) of Foxp3 in T cells associated with autoimmune disease and tolerance
3) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC3009635 Disease Relevance 0.76 Pain Relevance 0.20
However, Tr1 cells do not express Foxp3.
Neg (not) Gene_expression (express) of Foxp3 in Tr1 cells
4) Confidence 0.43 Published 2010 Journal Journal of Neuroinflammation Section Body Doc Link PMC3022819 Disease Relevance 0.29 Pain Relevance 0.27
The sections were stained to determine the expression levels of Foxp3 and Bcl-xL, using methods previously described by Khan et al [15] with slight modifications.
Spec (determine) Gene_expression (expression) of Foxp3
5) Confidence 0.43 Published 2010 Journal Journal of Neuroinflammation Section Body Doc Link PMC3022819 Disease Relevance 0 Pain Relevance 0
To distinguish between activated and regulatory CD4+ T cells, the expression of the transcription factor forkhead box protein 3 (FoxP3) that is mainly active in Treg [25] could be analyzed by rtPCR or by flow cytometry within infiltrating CD4+ T cells.
Gene_expression (expression) of FoxP3 in Treg
6) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956665 Disease Relevance 0 Pain Relevance 0
The sections were stained to determine the expression levels of Foxp3 and Bcl-xL, using methods previously described by Khan et al [15] with slight modifications.
Spec (determine) Gene_expression (levels) of Foxp3
7) Confidence 0.33 Published 2010 Journal Journal of Neuroinflammation Section Body Doc Link PMC3022819 Disease Relevance 0 Pain Relevance 0
An additional gene set was defined for NK cell activity and regulatory T cell activity was estimated from the expression of the FoxP3 gene (AF277993).
Gene_expression (expression) of FoxP3 in regulatory T cell
8) Confidence 0.16 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2569951 Disease Relevance 0 Pain Relevance 0
Histology of the colonic biopsy specimens revealed extensive infiltrates predominantly composed of CD8(+) T lymphocytes and evidence of high forkhead box P3 (FOXP3) expression.
Gene_expression (xpression.) of FOXP3 in T lymphocytes
9) Confidence 0.16 Published 2010 Journal Pediatrics Section Abstract Doc Link 20566611 Disease Relevance 1.78 Pain Relevance 0.31
No differences were observed in expression of FOXP3 and serum cytokines and population of CD4(+)CD25(high) T cells between CP/CPPS IIIA and IIIB patients.
Gene_expression (expression) of FOXP3 in T cells
10) Confidence 0.13 Published 2010 Journal Urology Section Body Doc Link 19800664 Disease Relevance 0.06 Pain Relevance 0
The frequency of CD4(+)CD25(high) T cells and FOXP3 expression level did not correlate with age, duration, and total national institutes of health-chronic prostatitis symptom index score of CP/CPPS patients.
Gene_expression (expression) of FOXP3 in T cells
11) Confidence 0.13 Published 2010 Journal Urology Section Body Doc Link 19800664 Disease Relevance 0 Pain Relevance 0
Unique to LCA-1 was a positive correlation between T reg (FoxP3) and CD14+ monocyte gene set expression (p < 0.10), a trait not identified in CFS and actually reversed in LCA-3.
Gene_expression (expression) of FoxP3 in monocyte associated with chronic fatigue syndrome
12) Confidence 0.13 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2569951 Disease Relevance 1.04 Pain Relevance 0
Finally expression of the T regulatory set (FoxP3) was marginally repressed in LCA class 1 (p = 0.09) which contained 40% of the CFS subjects though no significant difference was found for the larger CFS group (p = 0.31).
Gene_expression (expression) of FoxP3 associated with chronic fatigue syndrome
13) Confidence 0.13 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2569951 Disease Relevance 0.97 Pain Relevance 0

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