INT156900

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.19
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (ACTB) cytosol (ACTB) cytoskeleton (ACTB)
protein complex (ACTB) cytoplasm (ACTB)
ACTB (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 34 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 16 99.20 Very High Very High Very High
Osteoarthritis 38 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 5 5.00 Very Low Very Low Very Low
Arthropathy 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Real time reverse transcriptase polymerase chain reaction (RT-PCR) assessed MPG expression and three reference genes namely; beta Actin (ACTB), Glyceraldehyde three phosphate dehydrogenase (GAPDH) and Ubiquitin c (UBC).
Positive_regulation (assessed) of ACTB
1) Confidence 0.47 Published 2009 Journal J. Photochem. Photobiol. B, Biol. Section Body Doc Link 19101162 Disease Relevance 0 Pain Relevance 0
However, recent studies have shown that the expression stability of some of the commonly used reference genes, such as B2M, GAPDH and ACTB is not constant for all tissues or disease states [10,11].
Neg (not) Positive_regulation (constant) of ACTB associated with disease
2) Confidence 0.35 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC1884148 Disease Relevance 0.19 Pain Relevance 0
did not provoke significant differences of any reference gene except for ACTB which was significantly up-regulated in the glucosamine (Table 3) and diacerein (Table 5) experiments (p < 0.05).
Positive_regulation (up-regulated) of ACTB
3) Confidence 0.33 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1820791 Disease Relevance 0 Pain Relevance 0

General Comments

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