INT156908

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (THPO) extracellular space (THPO) extracellular region (THPO)
Anatomy Link Frequency
platelets 2
THPO (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 5 10.00 Low Low
fibrosis 10 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombocytopenia 94 74.72 Quite High
Heparin-induced Thrombocytopenia 6 50.00 Quite Low
Solid Tumor 4 50.00 Quite Low
Purpura 2 50.00 Quite Low
Hemorrhage 24 16.92 Low Low
Infection 8 16.24 Low Low
Fibrosis 10 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 10 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 10 5.00 Very Low Very Low Very Low
Myeloid Leukemia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are no known physiologic sensors of the platelet count or mass and studies have suggested that hepatic transcription and translation of the TPO gene to be constant.17,18 TPO is cleared by avid TPO receptors present on platelets and possibly megakaryocytes.
Transcription (transcription) of TPO in platelets
1) Confidence 0.69 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915538 Disease Relevance 0.07 Pain Relevance 0
There are no known physiologic sensors of the platelet count or mass and studies have suggested that hepatic transcription and translation of the TPO gene to be constant.17,18 TPO is cleared by avid TPO receptors present on platelets and possibly megakaryocytes.
Transcription (transcription) of TPO in platelets
2) Confidence 0.69 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915538 Disease Relevance 0.07 Pain Relevance 0
CONCLUSION: Compared with rhIL-11, administration of rhTPO after chemotherapy is safe and effective with mild adverse effects in reducing the degree and duration of thrombocytopenia.


Transcription (administration) of rhTPO
3) Confidence 0.60 Published 2008 Journal Zhonghua Zhong Liu Za Zhi Section Body Doc Link 19102944 Disease Relevance 0 Pain Relevance 0

General Comments

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