INT156920

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.66
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) cell-cell signaling (EDN1)
cytoplasm (EDN1)
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 3 98.98 Very High Very High Very High
Angina 1 52.88 Quite High
Osteoarthritis 35 31.44 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 2 93.52 High High
Increased Venous Pressure Under Development 3 92.48 High High
Coronary Vasospasm 3 79.72 Quite High
Osteoarthritis 36 50.00 Quite Low
Sprains And Strains 4 50.00 Quite Low
Apoptosis 14 41.44 Quite Low
Death 4 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 3 5.00 Very Low Very Low Very Low
Hypotension 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: The authors show that propofol inhibits strain-induced ET-1 expression, strain-increased reactive oxygen species formation, and extracellular signal-regulated protein kinase phosphorylation.
Phosphorylation (phosphorylation) of ET-1
1) Confidence 0.61 Published 2009 Journal Anesthesiology Section Body Doc Link 19104173 Disease Relevance 0 Pain Relevance 0
Furthermore, in the presence of PTIO, a nitric oxide scavenger, and KT5823, a specific inhibitor of cyclic guanosine monophosphate-dependent protein kinase, the inhibitory effect of propofol on strain-induced extracellular signal-regulated protein kinase phosphorylation and ET-1 release was reversed.
Phosphorylation (phosphorylation) of ET-1
2) Confidence 0.61 Published 2009 Journal Anesthesiology Section Body Doc Link 19104173 Disease Relevance 0 Pain Relevance 0
Figure 3a–d show the effects of ET-1 on the phosphorylation of p38, Akt, p44/42 and SAP/JNK kinases as detected by western blot of cell extracts.
Phosphorylation (phosphorylation) of ET-1
3) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0 Pain Relevance 0
The level of endothelin-converting enzyme was upregulated at that site where, upon exposure to serotonin, there were also increases in p47(phox), ROS, and ET-1 fluorescence intensities, and myosin light chain phosphorylation and RhoA activation were detected.
Phosphorylation (phosphorylation) of ET-1 associated with serotonin
4) Confidence 0.19 Published 2009 Journal Coron. Artery Dis. Section Abstract Doc Link 19623039 Disease Relevance 0.66 Pain Relevance 0.19

General Comments

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