INT156926

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.01
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Vsig2) biological_process (Vsig2)
Anatomy Link Frequency
urine 2
joint 1
cartilage 1
articular cartilage 1
Vsig2 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 143 91.92 High High
Pain 25 75.24 Quite High
metalloproteinase 2 28.08 Quite Low
Arthritis 4 21.72 Low Low
cINOD 9 5.00 Very Low Very Low Very Low
visual analogue scale 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Versed 4 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 18 99.72 Very High Very High Very High
Disease 42 98.88 Very High Very High Very High
Endometriosis (extended) 16 92.80 High High
Osteoarthritis 60 91.92 High High
Knee Osteoarthritis 42 91.04 High High
Frailty 42 90.96 High High
Injury 3 86.96 High High
Pain 24 75.24 Quite High
Obesity 7 38.12 Quite Low
Congenital Anomalies 1 28.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The CTX-II can reflect degradation of the articular cartilage.
Protein_catabolism (degradation) of CTX-II in articular cartilage
1) Confidence 0.57 Published 2008 Journal Zhongguo Gu Shang Section Abstract Doc Link 19105305 Disease Relevance 0.62 Pain Relevance 0.14
In urine a marker of cartilage degradation can be found, called CTX-II.
Protein_catabolism (degradation) of CTX-II in urine
2) Confidence 0.10 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1090586 Disease Relevance 0.23 Pain Relevance 0.11
Cartilage turnover was measured in urine by an immunoassay specific for collagen type II degradation products (CTX-II), and bone resorption was quantified in serum using an assay for bone collagen type I fragments (CTX-I).
Protein_catabolism (degradation) of CTX-II in urine associated with hypercalcemia
3) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC400436 Disease Relevance 0.26 Pain Relevance 0.08
Furthermore, the effects of cessation of endogenous estrogen production on bone and cartilage turnover were assessed using biochemical markers of collagen type I and II degradation (CTX-I and CTX-II).
Protein_catabolism (degradation) of CTX-II in cartilage
4) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400436 Disease Relevance 0.59 Pain Relevance 0.18
Both studies showed significant decreases in CTX-II, the marker of cartilage degradation, but these were not associated with an attenuation of joint-space loss This lack of association may be related to the length of observation in these studies.
Protein_catabolism (degradation) of CTX-II in joint
5) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174954 Disease Relevance 0.32 Pain Relevance 0.12

General Comments

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