INT156945

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 4.58
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
Notch 2
liver 2
neurons 2
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 9 99.84 Very High Very High Very High
Eae 7 96.60 Very High Very High Very High
Serotonin 1 86.84 High High
antidepressant 3 85.48 High High
Dopamine 11 83.20 Quite High
tolerance 38 81.96 Quite High
fluoxetine 1 80.32 Quite High
Kinase C 13 66.40 Quite High
Hippocampus 4 60.64 Quite High
Central nervous system 6 32.12 Quite Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 40 99.78 Very High Very High Very High
Targeted Disruption 89 97.04 Very High Very High Very High
Alzheimer's Dementia 6 93.52 High High
Diabetes Mellitus 32 93.36 High High
Death 40 91.52 High High
Manic Depressive Disorder 5 90.56 High High
Disease 90 89.84 High High
Shock 4 83.48 Quite High
Drug Induced Neurotoxicity 17 83.44 Quite High
Impaired Glucose Tolerance 28 81.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
loss in insulin-sensitive tissues, such as the liver, or whether the insulin sensitization is a consequence of the functional loss of GSK-3?
Positive_regulation (consequence) of Negative_regulation (loss) of GSK-3 in liver
1) Confidence 0.38 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.96 Pain Relevance 0.06
This unexpected result led us to initially infer that removal of hepatic GSK-3?
Positive_regulation (infer) of Negative_regulation (removal) of GSK-3
2) Confidence 0.34 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 1.19 Pain Relevance 0.11
might partially compensate for the loss of GSK3?
Spec (might) Positive_regulation (compensate) of Negative_regulation (loss) of GSK3
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0.23 Pain Relevance 0.07
Activation of the Akt kinase results in phosphorylation and consequent inactivation of GSK3?
Positive_regulation (results) of Negative_regulation (inactivation) of GSK3
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0
The pharmacological effects are mediated by the activation of Notch signaling in the NSC, but not by the inhibition of GSK-3b signaling or inositol depletion, currently popular models to explain mood stabilizers' action.
Neg (not) Positive_regulation (activation) of Negative_regulation (inhibition) of GSK-3b in Notch
5) Confidence 0.24 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 19108505 Disease Relevance 0.58 Pain Relevance 0.28
However, in our study, we show that, in vivo, MPTP treatment induces a progressive loss of TH-positive neurons concomitant with an increase of phospho-Tyr216 GSK-3?
Positive_regulation (induces) of Negative_regulation (loss) of GSK-3 in neurons associated with parkinson's disease
6) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.75 Pain Relevance 0
If the effects of LiCl are due to transient inhibition of GSK3?
Positive_regulation (due) of Negative_regulation (inhibition) of GSK3
7) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650783 Disease Relevance 0 Pain Relevance 0
In addition, M1 muscarinic receptor activation by the specific agonist AF267B induces the phosphorylation/inactivation of GSK-3?
Positive_regulation (induces) of Negative_regulation (inactivation) of GSK-3 associated with agonist
8) Confidence 0.07 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.87 Pain Relevance 0.31

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