INT156975

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 38.83
Pain Relevance 6.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B-cell 6
amygdala 2
endothelial cell 1
T lymphocyte 1
SLEB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 296 100.00 Very High Very High Very High
chemokine 248 100.00 Very High Very High Very High
cytokine 118 100.00 Very High Very High Very High
amygdala 58 100.00 Very High Very High Very High
Multiple sclerosis 388 99.96 Very High Very High Very High
cINOD 28 99.64 Very High Very High Very High
Osteoarthritis 57 99.60 Very High Very High Very High
Inflammation 128 98.78 Very High Very High Very High
Hippocampus 20 86.88 High High
tolerance 38 86.44 High High
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 1730 100.00 Very High Very High Very High
Disease 435 100.00 Very High Very High Very High
Rheumatoid Arthritis 296 100.00 Very High Very High Very High
Infection 79 100.00 Very High Very High Very High
Lymphatic System Cancer 16 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 15 100.00 Very High Very High Very High
Demyelinating Disease 242 99.96 Very High Very High Very High
Multiple Sclerosis 210 99.90 Very High Very High Very High
Autoimmune Disease 188 99.66 Very High Very High Very High
Osteoarthritis 60 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings extend our knowledge of susceptibility locus sharing across different autoimmune diseases, and provide convincing evidence that the RA/SLE locus 6q23/TNFAIP3 is a newly identified T1D locus.
Gene_expression (/) of SLE associated with autoimmune disease, diabetes mellitus, rheumatoid arthritis and systemic lupus erythematosus
1) Confidence 0.65 Published 2009 Journal Genes Immun. Section Abstract Doc Link 19110536 Disease Relevance 1.55 Pain Relevance 0.28
These findings extend our knowledge of susceptibility locus sharing across different autoimmune diseases, and provide convincing evidence that the RA/SLE locus 6q23/TNFAIP3 is a newly identified T1D locus.
Gene_expression (locus) of SLE associated with autoimmune disease, diabetes mellitus, rheumatoid arthritis and systemic lupus erythematosus
2) Confidence 0.65 Published 2009 Journal Genes Immun. Section Abstract Doc Link 19110536 Disease Relevance 1.55 Pain Relevance 0.28
These findings extend our knowledge of susceptibility locus sharing across different autoimmune diseases, and provide convincing evidence that the RA/SLE locus 6q23/TNFAIP3 is a newly identified T1D locus.
Gene_expression (/) of SLE associated with autoimmune disease, diabetes mellitus, rheumatoid arthritis and systemic lupus erythematosus
3) Confidence 0.65 Published 2009 Journal Genes Immun. Section Abstract Doc Link 19110536 Disease Relevance 1.55 Pain Relevance 0.28
The average ADC in the amygdala of patients with NP-SLE and SLE (940 × 10?
Gene_expression (average) of NP-SLE in amygdala associated with systemic lupus erythematosus and amygdala
4) Confidence 0.24 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1702559 Disease Relevance 0.98 Pain Relevance 0.43
The average ADC in the amygdala of patients with NP-SLE and SLE (940 × 10?
Gene_expression (The) of NP-SLE in amygdala associated with systemic lupus erythematosus and amygdala
5) Confidence 0.24 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1702559 Disease Relevance 0.98 Pain Relevance 0.43
The clinical expression of SLE is the consequence of its complex immunopathology, involving the production of autoantibodies and immune complex vasculitis with endothelial cell damage [1].
Gene_expression (expression) of SLE in endothelial cell associated with increased venous pressure under development and systemic lupus erythematosus
6) Confidence 0.09 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2765643 Disease Relevance 1.14 Pain Relevance 0.04
Although B-cell hyperreactivity and ANA production are characteristic hallmarks of CTD, especially SLE, serum ANAs are often found in subjects who do not fulfil the classification criteria for a CTD (22).
Gene_expression (hallmarks) of SLE in B-cell associated with systemic lupus erythematosus and disease
7) Confidence 0.08 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.40 Pain Relevance 0
However, the kinetic of PC expansion between infection and active SLE may differ.
Gene_expression (infection) of SLE associated with systemic lupus erythematosus and infection
8) Confidence 0.08 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 1.48 Pain Relevance 0
As shown in Table 2, a total of 21 miRNA were differentially expressed in the SLE-affected samples compared to the unaffected matched controls.
Gene_expression (expressed) of SLE associated with systemic lupus erythematosus
9) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867940 Disease Relevance 1.00 Pain Relevance 0
Moreover, VEGF reached the highest serum levels in patients with organ involvement, although no significant differences between the SLE groups with and without systemic manifestations were found.
Gene_expression (groups) of SLE associated with systemic lupus erythematosus
10) Confidence 0.07 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2765643 Disease Relevance 1.15 Pain Relevance 0
Therefore, the mechanism by which SLE differentially-expressed miRNAs affects a subset of target genes can be investigated by focusing on the pathway that leads to B-cell activation.
Gene_expression (expressed) of SLE in B-cell associated with systemic lupus erythematosus
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867940 Disease Relevance 1.25 Pain Relevance 0
Since case control studies are, in general, sensitive to population stratification, which may render the interpretation of results less than satisfactory, we also considered transmission disequilibrium tests using family data from three cohorts; the OSU MS samples, the MSGG MS samples, and Columbus Children's Hospital SLE samples.
Gene_expression (samples) of SLE associated with multiple sclerosis and systemic lupus erythematosus
12) Confidence 0.04 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.58 Pain Relevance 0.17
These results not only provide insight into the genetic basis of MS and SLE susceptibility, but, perhaps more importantly, to our knowledge, this is the first report that shows how polymorphisms at the 3?
Gene_expression (susceptibility) of SLE associated with multiple sclerosis and systemic lupus erythematosus
13) Confidence 0.04 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.88 Pain Relevance 0.15
18 years of age, were eligible to participate provided they had a diagnosis of SLE according to the American College of Rheumatology revised criteria (fulfilled ?
Gene_expression (diagnosis) of SLE associated with systemic lupus erythematosus
14) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526638 Disease Relevance 1.00 Pain Relevance 0.10
Evidence of clinical efficacy in indolent and aggressive NHL and in both SLE and pSS suggests that epratuzumab is a promising new therapeutic agent for the treatment of B-cell malignancies and B-cell-implicated autoimmune diseases.



Gene_expression (aggressive) of SLE in B-cell associated with autoimmune disease, lymphatic system cancer and systemic lupus erythematosus
15) Confidence 0.04 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376077 Disease Relevance 0.91 Pain Relevance 0
Our data suggest that the chronic inflammation in patients with RA and patients with SLE leads to changes in the chemokine receptor expression pattern on peripheral B cells; however, the expression patterns of chemokine receptors in RA and SLE are differentially regulated.


Gene_expression (expression) of SLE in B cells associated with chemokine, inflammation, rheumatoid arthritis and systemic lupus erythematosus
16) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 1.89 Pain Relevance 0.86
Analyses of chemokine receptor expression on peripheral blood B cell subsets of patients with RA, with SLE and with OA
Gene_expression (expression) of SLE in B cell associated with chemokine, rheumatoid arthritis, systemic lupus erythematosus and osteoarthritis
17) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 0.57 Pain Relevance 0.47
To what extent the described differences in chemokine receptor expression between B cells from patients with RA and patients with SLE might influence the migrational pattern of B cells needs to be delineated by continuing studies, potentially permitting new therapeutic avenues.


Gene_expression (expression) of SLE in B cells associated with chemokine, rheumatoid arthritis and systemic lupus erythematosus
18) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257429 Disease Relevance 1.71 Pain Relevance 0.85
The CTLR DC-SIGN, however, was also downregulated in SLE moDCs – both before and after stimulation (unstimulated percentage expression: control (n = 30), 71.3 ± 3.5 and SLE (n = 52), 53.2 ± 3.7; P = 0.005; stimulated percentage expression: control (n = 21), 64.7 ± 6.0 and SLE (n = 39), 48.6 ± 4.5; P = 0.03; Figure 5).
Gene_expression (expression) of SLE associated with systemic lupus erythematosus
19) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 1.25 Pain Relevance 0
In both unstimulated and stimulated lupus moDCs, the MR expression negatively correlated with SLE Disease Activity Index scores (unstimulated, r = -0.36, P = 0.006; stimulated, r = -0.48, P = 0.002; Figure 4a) and with serum anti-dsDNA titers (unstimulated, r = -0.35, P = 0.01; stimulated, r = -0.33, P = 0.04; Figure 4b).
Gene_expression (expression) of SLE associated with disease and systemic lupus erythematosus
20) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592801 Disease Relevance 1.05 Pain Relevance 0.14

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