INT156992

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Context Info
Confidence 0.68
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.77
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pdcd2) DNA binding (Pdcd2) cytoplasm (Pdcd2)
Pdcd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 2 100.00 Very High Very High Very High
Neuropathic pain 5 91.68 High High
Peripheral nerve injury 2 75.00 Quite High
intrathecal 2 70.84 Quite High
Sciatic nerve 1 70.32 Quite High
Spinal cord 1 37.52 Quite Low
Disease Link Frequency Relevance Heat
Hypersensitivity 6 100.00 Very High Very High Very High
Neuropathic Pain 5 91.68 High High
Nervous System Injury 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the selective inhibitor of NO-sensitive guanylyl cyclase 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and the guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase (PKG) inhibitor Rp-8-pCPT-cGMPS intrathecally exerted dose-dependent analgesic effects on thermal and mechanical hypersensitivity, spinally released NO most likely stimulates the NO-cGMP-PKG pathway.
Neg (NO) Localization (released) of Rp-8 associated with analgesic and hypersensitivity
1) Confidence 0.68 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19111753 Disease Relevance 0.77 Pain Relevance 0.55

General Comments

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