INT156993

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.06
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKG1) signal transduction (PRKG1) plasma membrane (PRKG1)
cytoplasm (PRKG1)
Anatomy Link Frequency
forebrain 1
neuromuscular junction 1
PRKG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 2 100.00 Very High Very High Very High
potassium channel 76 97.28 Very High Very High Very High
Endocannabinoid 22 96.40 Very High Very High Very High
Kinase C 44 94.16 High High
Neuropathic pain 5 92.28 High High
Neurotransmitter 22 88.12 High High
depression 22 79.12 Quite High
GABAergic 30 78.00 Quite High
Peripheral nerve injury 2 75.00 Quite High
intrathecal 2 71.44 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 11 100.00 Very High Very High Very High
Graves' Ophthalmopathy 2 92.96 High High
Neuropathic Pain 5 92.28 High High
Depression 22 79.12 Quite High
Nervous System Injury 4 75.00 Quite High
Parkinson's Disease 118 62.96 Quite High
Increased Venous Pressure Under Development 18 51.80 Quite High
Leukemia 1 41.40 Quite Low
Cv Unclassified Under Development 73 29.36 Quite Low
Cv General 3 Under Development 3 21.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
signaling, they do so by entirely independent mechanisms involving direct PKA- and PKG- mediated phosphorylation of TP?
Localization (do) of PKG
1) Confidence 0.35 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
They propose that cGMP activates PKG localized at the cytosolic surface of the mitochondrial outer membrane and that this phosphorylates some target protein which in turn can somehow activate PKC?
Localization (localized) of PKG associated with kinase c
2) Confidence 0.14 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.06 Pain Relevance 0.37
In the vertebrate (lizard) neuromuscular junction, endocannabinoid release underlay the transient suppression of acetylcholine release produced by activation of muscarinic (M3) receptors but, in order for the pathway to be effective, NO–cGMP and associated PKG were needed (Newman et al., 2007).
Localization (associated) of PKG in neuromuscular junction associated with endocannabinoid
3) Confidence 0.07 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0.17 Pain Relevance 0.41
Nevertheless, in forebrain cultures, brief (100 ms) puffs of NO elicited a rise in glial Ca2+ and the propagation of intercellular Ca2+ waves, due to cGMP–PKG promoting release from ryanodine-sensitive stores (Willmott et al., 2000).
Localization (release) of PKG in forebrain
4) Confidence 0.07 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0
Since the selective inhibitor of NO-sensitive guanylyl cyclase 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and the guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase (PKG) inhibitor Rp-8-pCPT-cGMPS intrathecally exerted dose-dependent analgesic effects on thermal and mechanical hypersensitivity, spinally released NO most likely stimulates the NO-cGMP-PKG pathway.
Localization (released) of PKG associated with analgesic and hypersensitivity
5) Confidence 0.06 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19111753 Disease Relevance 0.77 Pain Relevance 0.56
For instance, NO reportedly inhibits calcium sensitization by PKG-mediated inhibition of RhoA [34]–[35] and telokin [36], as well as by inhibition of RhoA activation through protein kinase A (PKA)-dependent phosphorylation of G?
Localization (sensitization) of PKG
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.05 Pain Relevance 0

General Comments

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