INT156997

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Context Info
Confidence 0.64
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 30.00
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NPC1) nuclear envelope (NPC1) endoplasmic reticulum (NPC1)
lysosome (NPC1)
Anatomy Link Frequency
plasma 4
blood 2
body 1
hippocampus 1
NPC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 10 99.46 Very High Very High Very High
Angina 1 92.72 High High
Neuritis 1 86.52 High High
ischemia 21 79.20 Quite High
cva 7 37.32 Quite Low
imagery 24 5.00 Very Low Very Low Very Low
anesthesia 19 5.00 Very Low Very Low Very Low
positron emission tomography 7 5.00 Very Low Very Low Very Low
Spinal cord 5 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nasopharynx Cancer 1519 100.00 Very High Very High Very High
Malignant Neoplastic Disease 160 100.00 Very High Very High Very High
Recurrence 22 100.00 Very High Very High Very High
Paraneoplastic Syndromes 7 99.50 Very High Very High Very High
Epstein-barr Virus 651 99.36 Very High Very High Very High
Infection 45 99.00 Very High Very High Very High
Alzheimer's Dementia 2 98.70 Very High Very High Very High
Cancer 888 98.40 Very High Very High Very High
Injury 18 97.52 Very High Very High Very High
Ovarian Cancer 26 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Familial clustering of NPC
Localization (clustering) of NPC associated with nasopharynx cancer
1) Confidence 0.64 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.69 Pain Relevance 0
susceptibility genes of NPC can be loosely categorized into 2 methodologies: a positional
Localization (categorized) of NPC associated with nasopharynx cancer
2) Confidence 0.64 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.45 Pain Relevance 0
Using proteinchip profiling analysis, two isoforms of serum amyloid A (SAA) protein were identified as useful biomarkers to monitor relapse of NPC.
Localization (relapse) of NPC associated with nasopharynx cancer, alzheimer's dementia and recurrence
3) Confidence 0.56 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.08 Pain Relevance 0
NPC is considered as surgically unresectable because of its anatomical localization.
Localization (localization) of NPC associated with nasopharynx cancer
4) Confidence 0.53 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC3019583 Disease Relevance 1.08 Pain Relevance 0.09
The plasma EBV DNA load was shown to be proportionately related to the presence of NPC.
Localization (presence) of NPC in plasma associated with nasopharynx cancer and epstein-barr virus
5) Confidence 0.52 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 2.12 Pain Relevance 0
The annual detection rate of NPC for this group was 31.7 times higher than for the population as a whole (21).
Localization (rate) of NPC associated with nasopharynx cancer
6) Confidence 0.52 Published 2010 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2848311 Disease Relevance 1.91 Pain Relevance 0
While some PNS will respond to direct treatment, most often the PNS subsides in parallel to response of the NPC, and thus may be useful for monitoring tumor response or recurrence.
Localization (response) of NPC associated with cancer, nasopharynx cancer, recurrence and paraneoplastic syndromes
7) Confidence 0.31 Published 2009 Journal Auris Nasus Larynx Section Abstract Doc Link 19111998 Disease Relevance 2.24 Pain Relevance 0.09
The aim of this study was to investigate secretion of BART miRNAs by NPC cells and their diffusion in the plasma of NPC-xenografted mice and NPC patients.
Spec (investigate) Localization (secretion) of NPC in plasma associated with nasopharynx cancer
8) Confidence 0.17 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.61 Pain Relevance 0
So far, however, it is not known whether the BART microRNAs (BART miRNAs) are secreted by NPC cells and whether they can be detected in the plasma and body fluids of NPC patients.
Localization (secreted) of NPC in body associated with nasopharynx cancer
9) Confidence 0.17 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.49 Pain Relevance 0
To address this question, we investigated by quantitative RT-PCR the status of 5 microRNAs from the BART family in exosomes released by NPC cells in vitro as well as in plasma samples from NPC xenografted nude mice and NPC patients.


Localization (released) of NPC in plasma associated with nasopharynx cancer
10) Confidence 0.17 Published 2010 Journal Virol J Section Abstract Doc Link PMC2974674 Disease Relevance 1.56 Pain Relevance 0
Therefore, we undertook to investigate the distribution of BART miRNAs in exosomes released by malignant NPC cells.
Localization (released) of NPC associated with malignant neoplastic disease and nasopharynx cancer
11) Confidence 0.17 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.30 Pain Relevance 0
Our data provide clear evidence that several BART miRNAs are secreted by C15 NPC cells in vitro in association with exosomes (Figure 3).
Localization (secreted) of NPC associated with nasopharynx cancer
12) Confidence 0.17 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.12 Pain Relevance 0
We demonstrate that BART miRNAs are secreted by NPC cells in vitro in association with exosomes (at least a fraction of them).
Localization (secreted) of NPC associated with nasopharynx cancer
13) Confidence 0.17 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.47 Pain Relevance 0
In this context, it was decided to investigate extra-cellular release of BART miRNAs by NPC cells and their possible detection in the blood of NPC patients.
Spec (investigate) Localization (release) of NPC in blood associated with nasopharynx cancer
14) Confidence 0.17 Published 2010 Journal Virol J Section Abstract Doc Link PMC2974674 Disease Relevance 1.41 Pain Relevance 0
Detection of BART miRNAs in exosomes released by NPC cells in vitro
Localization (released) of NPC associated with nasopharynx cancer
15) Confidence 0.17 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.45 Pain Relevance 0
The highest relative concentrations of BART miRNAs were detected in exosomes released by the C15 NPC cells, followed by exosomes from the NAD+C15 LCL (Figure 3).
Localization (released) of NPC associated with nasopharynx cancer
16) Confidence 0.17 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 0.72 Pain Relevance 0
This study provides the proof of principle that the BART miRNAs are secreted by NPC cells in vitro and in vivo and can diffuse from the tumor site to the blood stream.
Localization (secreted) of NPC in blood associated with cancer and nasopharynx cancer
17) Confidence 0.17 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 0.98 Pain Relevance 0
Viral BART miRNAs are secreted by NPC cells in vitro and in vivo.
Localization (secreted) of NPC associated with nasopharynx cancer
18) Confidence 0.17 Published 2010 Journal Virol J Section Abstract Doc Link PMC2974674 Disease Relevance 1.32 Pain Relevance 0
We report that the BART miRNAs are released in the extra-cellular space by NPC cells being associated, at least to a large extent, with secreted exosomes.
Localization (released) of NPC associated with nasopharynx cancer
19) Confidence 0.17 Published 2010 Journal Virol J Section Abstract Doc Link PMC2974674 Disease Relevance 1.47 Pain Relevance 0
So far, however, it is not known whether the BART microRNAs (BART miRNAs) are secreted by NPC cells and whether they can be detected in the plasma and body fluids of NPC patients.
Localization (secreted) of NPC in plasma associated with nasopharynx cancer
20) Confidence 0.06 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.49 Pain Relevance 0

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